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Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential.
Bujotzek A, Tiefenthaler G, Lariviere L, D'Andrea L, Marquez EA, Rudloff I, Cho SX, Deen NS, Richter W, Regenass-Lechner F, Poehler A, Whisstock JC, Sydow-Andersen J, Reiser X, Schuster S, Neubauer J, Hoepfl S, Richter K, Nold MF, Nold-Petry CA, Schumacher F, Ellisdon AM. Bujotzek A, et al. Among authors: schumacher f. Cell Chem Biol. 2022 Apr 21;29(4):586-596.e4. doi: 10.1016/j.chembiol.2021.10.004. Epub 2021 Oct 25. Cell Chem Biol. 2022. PMID: 34699747 Free article.
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Cho SX, Rudloff I, Lao JC, Pang MA, Goldberg R, Bui CB, McLean CA, Stock M, Klassert TE, Slevogt H, Mangan NE, Cheng W, Fischer D, Gfroerer S, Sandhu MK, Ngo D, Bujotzek A, Lariviere L, Schumacher F, Tiefenthaler G, Beker F, Collins C, Kamlin COF, König K, Malhotra A, Tan K, Theda C, Veldman A, Ellisdon AM, Whisstock JC, Berger PJ, Nold-Petry CA, Nold MF. Cho SX, et al. Among authors: schumacher f. Nat Commun. 2020 Nov 13;11(1):5794. doi: 10.1038/s41467-020-19400-w. Nat Commun. 2020. PMID: 33188181 Free PMC article.
Diligent Design Enables Antibody-ASO Conjugates with Optimal Pharmacokinetic Properties.
Sela T, Mansø M, Siegel M, Marban-Doran C, Ducret A, Niewöhner J, Ravn J, Martin RE, Sommer A, Lohmann S, Krippendorff BF, Ladefoged M, Indlekofer A, Quaiser T, Bueddefeld F, Koller E, Mohamed MY, Oelschlaegel T, Gothelf KV, Hofer K, Schumacher FF. Sela T, et al. Among authors: schumacher ff. Bioconjug Chem. 2023 Nov 15;34(11):2096-2111. doi: 10.1021/acs.bioconjchem.3c00393. Epub 2023 Nov 2. Bioconjug Chem. 2023. PMID: 37916986
Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics.
Tyshchuk O, Gstöttner C, Funk D, Nicolardi S, Frost S, Klostermann S, Becker T, Jolkver E, Schumacher F, Koller CF, Völger HR, Wuhrer M, Bulau P, Mølhøj M. Tyshchuk O, et al. Among authors: schumacher f. MAbs. 2019 Oct;11(7):1219-1232. doi: 10.1080/19420862.2019.1635865. Epub 2019 Jul 24. MAbs. 2019. PMID: 31339437 Free PMC article.
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.
Chen Z, Guo X, Tao R, Huyghe JR, Law PJ, Fernandez-Rozadilla C, Ping J, Jia G, Long J, Li C, Shen Q, Xie Y, Timofeeva MN, Thomas M, Schmit SL, Díez-Obrero V, Devall M, Moratalla-Navarro F, Fernandez-Tajes J, Palles C, Sherwood K, Briggs SEW, Svinti V, Donnelly K, Farrington SM, Blackmur J, Vaughan-Shaw PG, Shu XO, Lu Y, Broderick P, Studd J, Harrison TA, Conti DV, Schumacher FR, Melas M, Rennert G, Obón-Santacana M, Martín-Sánchez V, Oh JH, Kim J, Jee SH, Jung KJ, Kweon SS, Shin MH, Shin A, Ahn YO, Kim DH, Oze I, Wen W, Matsuo K, Matsuda K, Tanikawa C, Ren Z, Gao YT, Jia WH, Hopper JL, Jenkins MA, Win AK, Pai RK, Figueiredo JC, Haile RW, Gallinger S, Woods MO, Newcomb PA, Duggan D, Cheadle JP, Kaplan R, Kerr R, Kerr D, Kirac I, Böhm J, Mecklin JP, Jousilahti P, Knekt P, Aaltonen LA, Rissanen H, Pukkala E, Eriksson JG, Cajuso T, Hänninen U, Kondelin J, Palin K, Tanskanen T, Renkonen-Sinisalo L, Männistö S, Albanes D, Weinstein SJ, Ruiz-Narvaez E, Palmer JR, Buchanan DD, Platz EA, Visvanathan K, Ulrich CM, Siegel E, Brezina S, Gsur A, Campbell PT, Chang-Claude J, Hoffmeister M, Brenner H, Slattery ML, Potter JD, Tsilidis KK, Schulze MB, Gunter MJ, Murphy N, Castells A, Castel… See abstract for full author list ➔ Chen Z, et al. Among authors: schumacher fr. Nat Commun. 2024 Apr 26;15(1):3557. doi: 10.1038/s41467-024-47399-x. Nat Commun. 2024. PMID: 38670944 Free PMC article.
501 results