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SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme.
Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P, Dankworth B, Alibhai D, Harris AL, Schulze A. Lewis CA, et al. Among authors: schulze a. Oncogene. 2015 Oct 1;34(40):5128-40. doi: 10.1038/onc.2014.439. Epub 2015 Jan 26. Oncogene. 2015. PMID: 25619842
The multifaceted roles of fatty acid synthesis in cancer.
Röhrig F, Schulze A. Röhrig F, et al. Among authors: schulze a. Nat Rev Cancer. 2016 Nov;16(11):732-749. doi: 10.1038/nrc.2016.89. Epub 2016 Sep 23. Nat Rev Cancer. 2016. PMID: 27658529 Review.
Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation.
Bartmann C, Janaki Raman SR, Flöter J, Schulze A, Bahlke K, Willingstorfer J, Strunz M, Wöckel A, Klement RJ, Kapp M, Djuzenova CS, Otto C, Kämmerer U. Bartmann C, et al. Among authors: schulze a. Cancer Metab. 2018 Jun 11;6:8. doi: 10.1186/s40170-018-0180-9. eCollection 2018. Cancer Metab. 2018. PMID: 29942509 Free PMC article.
The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth.
Gouw AM, Margulis K, Liu NS, Raman SJ, Mancuso A, Toal GG, Tong L, Mosley A, Hsieh AL, Sullivan DK, Stine ZE, Altman BJ, Schulze A, Dang CV, Zare RN, Felsher DW. Gouw AM, et al. Among authors: schulze a. Cell Metab. 2019 Sep 3;30(3):556-572.e5. doi: 10.1016/j.cmet.2019.07.012. Epub 2019 Aug 22. Cell Metab. 2019. PMID: 31447321 Free PMC article.
Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.
Kaymak I, Maier CR, Schmitz W, Campbell AD, Dankworth B, Ade CP, Walz S, Paauwe M, Kalogirou C, Marouf H, Rosenfeldt MT, Gay DM, McGregor GH, Sansom OJ, Schulze A. Kaymak I, et al. Among authors: schulze a. Cancer Res. 2020 Jan 15;80(2):189-203. doi: 10.1158/0008-5472.CAN-19-0650. Epub 2019 Nov 19. Cancer Res. 2020. PMID: 31744820
901 results