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Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection.
Di Cristina M, Dou Z, Lunghi M, Kannan G, Huynh MH, McGovern OL, Schultz TL, Schultz AJ, Miller AJ, Hayes BM, van der Linden W, Emiliani C, Bogyo M, Besteiro S, Coppens I, Carruthers VB. Di Cristina M, et al. Among authors: schultz aj, schultz tl. Nat Microbiol. 2017 Jun 19;2:17096. doi: 10.1038/nmicrobiol.2017.96. Nat Microbiol. 2017. PMID: 28628099 Free PMC article.
Cerebral complement C1q activation in chronic Toxoplasma infection.
Xiao J, Li Y, Gressitt KL, He H, Kannan G, Schultz TL, Svezhova N, Carruthers VB, Pletnikov MV, Yolken RH, Severance EG. Xiao J, et al. Among authors: schultz tl. Brain Behav Immun. 2016 Nov;58:52-56. doi: 10.1016/j.bbi.2016.04.009. Epub 2016 Apr 22. Brain Behav Immun. 2016. PMID: 27109609 Free PMC article.
Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
Vidadala RS, Rivas KL, Ojo KK, Hulverson MA, Zambriski JA, Bruzual I, Schultz TL, Huang W, Zhang Z, Scheele S, DeRocher AE, Choi R, Barrett LK, Siddaramaiah LK, Hol WG, Fan E, Merritt EA, Parsons M, Freiberg G, Marsh K, Kempf DJ, Carruthers VB, Isoherranen N, Doggett JS, Van Voorhis WC, Maly DJ. Vidadala RS, et al. Among authors: schultz tl. J Med Chem. 2016 Jul 14;59(13):6531-46. doi: 10.1021/acs.jmedchem.6b00760. Epub 2016 Jul 1. J Med Chem. 2016. PMID: 27309760 Free PMC article.
22 results