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Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I. Shin D, et al. Among authors: schulman ba. Nature. 2020 Nov;587(7835):657-662. doi: 10.1038/s41586-020-2601-5. Epub 2020 Jul 29. Nature. 2020. PMID: 32726803 Free PMC article.
A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.
Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H. Mulder MP, et al. Among authors: schulman ba. Nat Chem Biol. 2016 Jul;12(7):523-30. doi: 10.1038/nchembio.2084. Epub 2016 May 16. Nat Chem Biol. 2016. PMID: 27182664 Free PMC article.
Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Scott DC, Hammill JT, Min J, Rhee DY, Connelly M, Sviderskiy VO, Bhasin D, Chen Y, Ong SS, Chai SC, Goktug AN, Huang G, Monda JK, Low J, Kim HS, Paulo JA, Cannon JR, Shelat AA, Chen T, Kelsall IR, Alpi AF, Pagala V, Wang X, Peng J, Singh B, Harper JW, Schulman BA, Guy RK. Scott DC, et al. Among authors: schulman ba. Nat Chem Biol. 2017 Aug;13(8):850-857. doi: 10.1038/nchembio.2386. Epub 2017 Jun 5. Nat Chem Biol. 2017. PMID: 28581483 Free PMC article.
Molecular glue concept solidifies.
Baek K, Schulman BA. Baek K, et al. Among authors: schulman ba. Nat Chem Biol. 2020 Jan;16(1):2-3. doi: 10.1038/s41589-019-0414-3. Nat Chem Biol. 2020. PMID: 31819271 No abstract available.
NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Baek K, Krist DT, Prabu JR, Hill S, Klügel M, Neumaier LM, von Gronau S, Kleiger G, Schulman BA. Baek K, et al. Among authors: schulman ba. Nature. 2020 Feb;578(7795):461-466. doi: 10.1038/s41586-020-2000-y. Epub 2020 Feb 12. Nature. 2020. PMID: 32051583 Free PMC article.
NEDD8 and ubiquitin ligation by cullin-RING E3 ligases.
Baek K, Scott DC, Schulman BA. Baek K, et al. Among authors: schulman ba. Curr Opin Struct Biol. 2021 Apr;67:101-109. doi: 10.1016/j.sbi.2020.10.007. Epub 2020 Nov 5. Curr Opin Struct Biol. 2021. PMID: 33160249 Free PMC article. Review.
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA. Liwocha J, et al. Among authors: schulman ba. Nat Chem Biol. 2021 Mar;17(3):272-279. doi: 10.1038/s41589-020-00696-0. Epub 2020 Dec 7. Nat Chem Biol. 2021. PMID: 33288957 Free PMC article.
Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klügel M, Scott DC, Ovaa H, Kleiger G, Schulman BA. Horn-Ghetko D, et al. Among authors: schulman ba. Nature. 2021 Feb;590(7847):671-676. doi: 10.1038/s41586-021-03197-9. Epub 2021 Feb 3. Nature. 2021. PMID: 33536622 Free PMC article.
199 results