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Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.
Boija A, Klein IA, Sabari BR, Dall'Agnese A, Coffey EL, Zamudio AV, Li CH, Shrinivas K, Manteiga JC, Hannett NM, Abraham BJ, Afeyan LK, Guo YE, Rimel JK, Fant CB, Schuijers J, Lee TI, Taatjes DJ, Young RA. Boija A, et al. Among authors: schuijers j. Cell. 2018 Dec 13;175(7):1842-1855.e16. doi: 10.1016/j.cell.2018.10.042. Epub 2018 Nov 15. Cell. 2018. PMID: 30449618 Free PMC article.
Coactivator condensation at super-enhancers links phase separation and gene control.
Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA. Sabari BR, et al. Among authors: schuijers j. Science. 2018 Jul 27;361(6400):eaar3958. doi: 10.1126/science.aar3958. Epub 2018 Jun 21. Science. 2018. PMID: 29930091 Free PMC article.
Enhancer Features that Drive Formation of Transcriptional Condensates.
Shrinivas K, Sabari BR, Coffey EL, Klein IA, Boija A, Zamudio AV, Schuijers J, Hannett NM, Sharp PA, Young RA, Chakraborty AK. Shrinivas K, et al. Among authors: schuijers j. Mol Cell. 2019 Aug 8;75(3):549-561.e7. doi: 10.1016/j.molcel.2019.07.009. Mol Cell. 2019. PMID: 31398323 Free PMC article.
Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes.
Zamudio AV, Dall'Agnese A, Henninger JE, Manteiga JC, Afeyan LK, Hannett NM, Coffey EL, Li CH, Oksuz O, Sabari BR, Boija A, Klein IA, Hawken SW, Spille JH, Decker TM, Cisse II, Abraham BJ, Lee TI, Taatjes DJ, Schuijers J, Young RA. Zamudio AV, et al. Among authors: schuijers j. Mol Cell. 2019 Dec 5;76(5):753-766.e6. doi: 10.1016/j.molcel.2019.08.016. Epub 2019 Sep 25. Mol Cell. 2019. PMID: 31563432 Free PMC article.
MeCP2 links heterochromatin condensates and neurodevelopmental disease.
Li CH, Coffey EL, Dall'Agnese A, Hannett NM, Tang X, Henninger JE, Platt JM, Oksuz O, Zamudio AV, Afeyan LK, Schuijers J, Liu XS, Markoulaki S, Lungjangwa T, LeRoy G, Svoboda DS, Wogram E, Lee TI, Jaenisch R, Young RA. Li CH, et al. Among authors: schuijers j. Nature. 2020 Oct;586(7829):440-444. doi: 10.1038/s41586-020-2574-4. Epub 2020 Jul 22. Nature. 2020. PMID: 32698189 Free PMC article.
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions.
Verzi MP, Hatzis P, Sulahian R, Philips J, Schuijers J, Shin H, Freed E, Lynch JP, Dang DT, Brown M, Clevers H, Liu XS, Shivdasani RA. Verzi MP, et al. Among authors: schuijers j. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15157-62. doi: 10.1073/pnas.1003822107. Epub 2010 Aug 9. Proc Natl Acad Sci U S A. 2010. PMID: 20696899 Free PMC article.
42 results