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SARS-CoV-2 Mpro responds to oxidation by forming disulfide and NOS/SONOS bonds.
Reinke PYA, Schubert R, Oberthür D, Galchenkova M, Rahmani Mashhour A, Günther S, Chretien A, Round A, Seychell BC, Norton-Baker B, Kim C, Schmidt C, Koua FHM, Tolstikova A, Ewert W, Peña Murillo GE, Mills G, Kirkwood H, Brognaro H, Han H, Koliyadu J, Schulz J, Bielecki J, Lieske J, Maracke J, Knoska J, Lorenzen K, Brings L, Sikorski M, Kloos M, Vakili M, Vagovic P, Middendorf P, de Wijn R, Bean R, Letrun R, Han S, Falke S, Geng T, Sato T, Srinivasan V, Kim Y, Yefanov OM, Gelisio L, Beck T, Doré AS, Mancuso AP, Betzel C, Bajt S, Redecke L, Chapman HN, Meents A, Turk D, Hinrichs W, Lane TJ. Reinke PYA, et al. Among authors: schubert r. Nat Commun. 2024 May 7;15(1):3827. doi: 10.1038/s41467-024-48109-3. Nat Commun. 2024. PMID: 38714735 Free PMC article.
Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study.
Reilmann R, Anderson KE, Feigin A, Tabrizi SJ, Leavitt BR, Stout JC, Piccini P, Schubert R, Loupe P, Wickenberg A, Borowsky B, Rynkowski G, Volkinshtein R, Li T, Savola JM, Hayden M, Gordon MF; LEGATO-HD Study Group. Reilmann R, et al. Among authors: schubert r. Lancet Neurol. 2024 Mar;23(3):243-255. doi: 10.1016/S1474-4422(23)00454-4. Epub 2024 Jan 24. Lancet Neurol. 2024. PMID: 38280392 Clinical Trial.
Light-induced Trpin/Metout Switching During BLUF Domain Activation in ATP-bound Photoactivatable Adenylate Cyclase OaPAC.
Chretien A, Nagel MF, Botha S, de Wijn R, Brings L, Dörner K, Han H, Koliyadu JCP, Letrun R, Round A, Sato T, Schmidt C, Secareanu RC, von Stetten D, Vakili M, Wrona A, Bean R, Mancuso A, Schulz J, Pearson AR, Kottke T, Lorenzen K, Schubert R. Chretien A, et al. Among authors: schubert r. J Mol Biol. 2024 Mar 1;436(5):168439. doi: 10.1016/j.jmb.2024.168439. Epub 2024 Jan 5. J Mol Biol. 2024. PMID: 38185322 Free article.
Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis.
Frueh JT, Campe J, Sunaga-Franze DY, Verheyden NA, Ghimire S, Meedt E, Haslinger D, Harenkamp S, Staudenraus D, Sauer S, Kreft A, Schubert R, Lohoff M, Krueger A, Bonig H, Chiocchetti AG, Zeiser R, Holler E, Ullrich E. Frueh JT, et al. Among authors: schubert r. Oncoimmunology. 2023 Dec 27;13(1):2296712. doi: 10.1080/2162402X.2023.2296712. eCollection 2024. Oncoimmunology. 2023. PMID: 38170159 Free PMC article.
Time-resolved crystallography captures light-driven DNA repair.
Christou NE, Apostolopoulou V, Melo DVM, Ruppert M, Fadini A, Henkel A, Sprenger J, Oberthuer D, Günther S, Pateras A, Rahmani Mashhour A, Yefanov OM, Galchenkova M, Reinke PYA, Kremling V, Scheer TES, Lange ER, Middendorf P, Schubert R, De Zitter E, Lumbao-Conradson K, Herrmann J, Rahighi S, Kunavar A, Beale EV, Beale JH, Cirelli C, Johnson PJM, Dworkowski F, Ozerov D, Bertrand Q, Wranik M, Bacellar C, Bajt S, Wakatsuki S, Sellberg JA, Huse N, Turk D, Chapman HN, Lane TJ. Christou NE, et al. Among authors: schubert r. Science. 2023 Dec;382(6674):1015-1020. doi: 10.1126/science.adj4270. Epub 2023 Nov 30. Science. 2023. PMID: 38033070
Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX.
Williamson LJ, Galchenkova M, Best HL, Bean RJ, Munke A, Awel S, Pena G, Knoska J, Schubert R, Dörner K, Park HW, Bideshi DK, Henkel A, Kremling V, Klopprogge B, Lloyd-Evans E, Young MT, Valerio J, Kloos M, Sikorski M, Mills G, Bielecki J, Kirkwood H, Kim C, de Wijn R, Lorenzen K, Xavier PL, Rahmani Mashhour A, Gelisio L, Yefanov O, Mancuso AP, Federici BA, Chapman HN, Crickmore N, Rizkallah PJ, Berry C, Oberthür D. Williamson LJ, et al. Among authors: schubert r. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2203241120. doi: 10.1073/pnas.2203241120. Epub 2023 Nov 28. Proc Natl Acad Sci U S A. 2023. PMID: 38015839 Free PMC article.
Anticarcinogenic Potency of EF24: An Overview of Its Pharmacokinetics, Efficacy, Mechanism of Action, and Nanoformulation for Drug Delivery.
Sazdova I, Keremidarska-Markova M, Dimitrova D, Mitrokhin V, Kamkin A, Hadzi-Petrushev N, Bogdanov J, Schubert R, Gagov H, Avtanski D, Mladenov M. Sazdova I, et al. Among authors: schubert r. Cancers (Basel). 2023 Nov 20;15(22):5478. doi: 10.3390/cancers15225478. Cancers (Basel). 2023. PMID: 38001739 Free PMC article. Review.
957 results