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Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement.
Johnson DB, Nixon MJ, Wang Y, Wang DY, Castellanos E, Estrada MV, Ericsson-Gonzalez PI, Cote CH, Salgado R, Sanchez V, Dean PT, Opalenik SR, Schreeder DM, Rimm DL, Kim JY, Bordeaux J, Loi S, Horn L, Sanders ME, Ferrell PB Jr, Xu Y, Sosman JA, Davis RS, Balko JM. Johnson DB, et al. Among authors: schreeder dm. JCI Insight. 2018 Dec 20;3(24):e120360. doi: 10.1172/jci.insight.120360. JCI Insight. 2018. PMID: 30568030 Free PMC article.
Cutting edge: FcR-like 6 is an MHC class II receptor.
Schreeder DM, Cannon JP, Wu J, Li R, Shakhmatov MA, Davis RS. Schreeder DM, et al. J Immunol. 2010 Jul 1;185(1):23-7. doi: 10.4049/jimmunol.1000832. Epub 2010 Jun 2. J Immunol. 2010. PMID: 20519654 Free PMC article.
Fc receptor-like proteins (FCRL): immunomodulators of B cell function.
Ehrhardt GR, Leu CM, Zhang S, Aksu G, Jackson T, Haga C, Hsu JT, Schreeder DM, Davis RS, Cooper MD. Ehrhardt GR, et al. Among authors: schreeder dm. Adv Exp Med Biol. 2007;596:155-62. doi: 10.1007/0-387-46530-8_14. Adv Exp Med Biol. 2007. PMID: 17338184 Review. No abstract available.
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Kim MY, Yu KR, Kenderian SS, Ruella M, Chen S, Shin TH, Aljanahi AA, Schreeder D, Klichinsky M, Shestova O, Kozlowski MS, Cummins KD, Shan X, Shestov M, Bagg A, Morrissette JJD, Sekhri P, Lazzarotto CR, Calvo KR, Kuhns DB, Donahue RE, Behbehani GK, Tsai SQ, Dunbar CE, Gill S. Kim MY, et al. Cell. 2018 May 31;173(6):1439-1453.e19. doi: 10.1016/j.cell.2018.05.013. Epub 2018 May 31. Cell. 2018. PMID: 29856956 Free PMC article.