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Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.
Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Pawlikowski JS, Norris KT, Criscione SW, Pchelintsev NA, Piscitello D, Stong N, Rai TS, McBryan T, Otte GL, Nixon C, Clark W, Riethman H, Wu H, Schotta G, Garcia BA, Neretti N, Baird DM, Berger SL, Adams PD. Nelson DM, et al. Among authors: schotta g. Genome Biol. 2016 Jul 25;17(1):158. doi: 10.1186/s13059-016-1017-x. Genome Biol. 2016. PMID: 27457071 Free PMC article.
Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.
Hahn M, Dambacher S, Dulev S, Kuznetsova AY, Eck S, Wörz S, Sadic D, Schulte M, Mallm JP, Maiser A, Debs P, von Melchner H, Leonhardt H, Schermelleh L, Rohr K, Rippe K, Storchova Z, Schotta G. Hahn M, et al. Among authors: schotta g. Genes Dev. 2013 Apr 15;27(8):859-72. doi: 10.1101/gad.210377.112. Epub 2013 Apr 18. Genes Dev. 2013. PMID: 23599346 Free PMC article.
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
Bromberg KD, Mitchell TR, Upadhyay AK, Jakob CG, Jhala MA, Comess KM, Lasko LM, Li C, Tuzon CT, Dai Y, Li F, Eram MS, Nuber A, Soni NB, Manaves V, Algire MA, Sweis RF, Torrent M, Schotta G, Sun C, Michaelides MR, Shoemaker AR, Arrowsmith CH, Brown PJ, Santhakumar V, Martin A, Rice JC, Chiang GG, Vedadi M, Barsyte-Lovejoy D, Pappano WN. Bromberg KD, et al. Among authors: schotta g. Nat Chem Biol. 2017 Mar;13(3):317-324. doi: 10.1038/nchembio.2282. Epub 2017 Jan 23. Nat Chem Biol. 2017. PMID: 28114273
CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.
Dambacher S, Deng W, Hahn M, Sadic D, Fröhlich J, Nuber A, Hoischen C, Diekmann S, Leonhardt H, Schotta G. Dambacher S, et al. Among authors: schotta g. Nucleus. 2012 Jan-Feb;3(1):101-10. doi: 10.4161/nucl.18955. Nucleus. 2012. PMID: 22540025 Free PMC article.
85 results