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Novel alpha6 preferring GABA-A receptor ligands based on loreclezole.
Simeone X, Ernst M, Seidel T, Heider J, Enz D, Monticelli S, Vogel FD, Koniuszewski F, Langer T, Scholze P, Pace V, Miele M. Simeone X, et al. Among authors: scholze p. Eur J Med Chem. 2022 Dec 15;244:114780. doi: 10.1016/j.ejmech.2022.114780. Epub 2022 Sep 17. Eur J Med Chem. 2022. PMID: 36279694
Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.
David R, Ciuraszkiewicz A, Simeone X, Orr-Urtreger A, Papke RL, McIntosh JM, Huck S, Scholze P. David R, et al. Among authors: scholze p. Eur J Neurosci. 2010 Mar;31(6):978-93. doi: 10.1111/j.1460-9568.2010.07133.x. Epub 2010 Mar 3. Eur J Neurosci. 2010. PMID: 20377613 Free PMC article.
Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit.
Stamenić TT, Poe MM, Rehman S, Santrač A, Divović B, Scholze P, Ernst M, Cook JM, Savić MM. Stamenić TT, et al. Among authors: scholze p. Eur J Pharmacol. 2016 Nov 15;791:433-443. doi: 10.1016/j.ejphar.2016.09.016. Epub 2016 Sep 14. Eur J Pharmacol. 2016. PMID: 27639297 Free PMC article.
Different Benzodiazepines Bind with Distinct Binding Modes to GABAA Receptors.
Elgarf AA, Siebert DCB, Steudle F, Draxler A, Li G, Huang S, Cook JM, Ernst M, Scholze P. Elgarf AA, et al. Among authors: scholze p. ACS Chem Biol. 2018 Aug 17;13(8):2033-2039. doi: 10.1021/acschembio.8b00144. Epub 2018 Jul 23. ACS Chem Biol. 2018. PMID: 29767950 Free PMC article.
71 results