Scholten DJ - Search Results

1

Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands.

Wijtmans M, Scholten DJ, Roumen L, Canals M, Custers H, Glas M, Vreeker MC, de Kanter FJ, de Graaf C, Smit MJ, de Esch IJ, Leurs R. Wijtmans M, et al. Among authors: scholten dj. J Med Chem. 2012 Dec 13;55(23):10572-83. doi: 10.1021/jm301240t. Epub 2012 Nov 14. J Med Chem. 2012. PMID: 23150943

2

Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3.

Scholten DJ, Canals M, Wijtmans M, de Munnik S, Nguyen P, Verzijl D, de Esch IJ, Vischer HF, Smit MJ, Leurs R. Scholten DJ, et al. Br J Pharmacol. 2012 Jun;166(3):898-911. doi: 10.1111/j.1476-5381.2011.01648.x. Br J Pharmacol. 2012. PMID: 21883151 Free PMC article.

3

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists.

Wijtmans M, Maussang D, Sirci F, Scholten DJ, Canals M, Mujić-Delić A, Chong M, Chatalic KL, Custers H, Janssen E, de Graaf C, Smit MJ, de Esch IJ, Leurs R. Wijtmans M, et al. Among authors: scholten dj. Eur J Med Chem. 2012 May;51:184-92. doi: 10.1016/j.ejmech.2012.02.041. Epub 2012 Feb 27. Eur J Med Chem. 2012. PMID: 22424612

4

Pharmacological characterization of [3H]VUF11211, a novel radiolabeled small-molecule inverse agonist for the chemokine receptor CXCR3.

Scholten DJ, Wijtmans M, van Senten JR, Custers H, Stunnenberg A, de Esch IJ, Smit MJ, Leurs R. Scholten DJ, et al. Mol Pharmacol. 2015 Apr;87(4):639-48. doi: 10.1124/mol.114.095265. Epub 2015 Jan 9. Mol Pharmacol. 2015. PMID: 25576486

5

Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment.

Mladic M, Scholten DJ, Wijtmans M, Falck D, Leurs R, Niessen WM, Smit MJ, Kool J. Mladic M, et al. Among authors: scholten dj. Anal Bioanal Chem. 2015 Sep;407(23):7067-81. doi: 10.1007/s00216-015-8867-z. Epub 2015 Jul 12. Anal Bioanal Chem. 2015. PMID: 26164305 Free PMC article.

6

Pharmacological modulation of chemokine receptor function.

Scholten DJ, Canals M, Maussang D, Roumen L, Smit MJ, Wijtmans M, de Graaf C, Vischer HF, Leurs R. Scholten DJ, et al. Br J Pharmacol. 2012 Mar;165(6):1617-1643. doi: 10.1111/j.1476-5381.2011.01551.x. Br J Pharmacol. 2012. PMID: 21699506 Free PMC article. Review.

7

C(X)CR in silico: Computer-aided prediction of chemokine receptor-ligand interactions.

Roumen L, Scholten DJ, de Kruijf P, de Esch IJ, Leurs R, de Graaf C. Roumen L, et al. Among authors: scholten dj. Drug Discov Today Technol. 2012 Winter;9(4):e281-91. doi: 10.1016/j.ddtec.2012.05.002. Drug Discov Today Technol. 2012. PMID: 24990665

8

Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors.

Verzijl D, Storelli S, Scholten DJ, Bosch L, Reinhart TA, Streblow DN, Tensen CP, Fitzsimons CP, Zaman GJ, Pease JE, de Esch IJ, Smit MJ, Leurs R. Verzijl D, et al. Among authors: scholten dj. J Pharmacol Exp Ther. 2008 May;325(2):544-55. doi: 10.1124/jpet.107.134783. Epub 2008 Feb 12. J Pharmacol Exp Ther. 2008. PMID: 18270317 Free PMC article.

9

Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with Gi-protein pathway activation.

Watts AO, Scholten DJ, Heitman LH, Vischer HF, Leurs R. Watts AO, et al. Among authors: scholten dj. Biochem Biophys Res Commun. 2012 Mar 9;419(2):412-8. doi: 10.1016/j.bbrc.2012.02.036. Epub 2012 Feb 13. Biochem Biophys Res Commun. 2012. PMID: 22349504

10

Ubiquitination of CXCR7 controls receptor trafficking.

Canals M, Scholten DJ, de Munnik S, Han MK, Smit MJ, Leurs R. Canals M, et al. Among authors: scholten dj. PLoS One. 2012;7(3):e34192. doi: 10.1371/journal.pone.0034192. Epub 2012 Mar 23. PLoS One. 2012. PMID: 22457824 Free PMC article.

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