Schofield CJ - Search Results

1

Editorial overview: 'The amazing power of physics to provide chemical insight into catalysis and regulation' … something better ….

Parker EJ, Schofield CJ. Parker EJ, et al. Among authors: schofield cj. Curr Opin Struct Biol. 2024 Feb;84:102763. doi: 10.1016/j.sbi.2023.102763. Epub 2024 Jan 23. Curr Opin Struct Biol. 2024. PMID: 38266470 No abstract available.

2

Catalysis by KDM6 Histone Demethylases - A Synergy between the Non-Heme Iron(II) Center, Second Coordination Sphere, and Long-Range Interactions.

Rifayee SBJS, Chaturvedi SS, Warner C, Wildey J, White W, Thompson M, Schofield CJ, Christov CZ. Rifayee SBJS, et al. Among authors: schofield cj. Chemistry. 2023 Sep 12;29(51):e202301305. doi: 10.1002/chem.202301305. Epub 2023 Jul 26. Chemistry. 2023. PMID: 37258457

3

Photoaffinity labelling displacement assay using multiple recombinant protein domains.

Fallon DJ, Phillipou A, Schofield CJ, House D, Tomkinson NCO, Bush JT. Fallon DJ, et al. Among authors: schofield cj. Biochem J. 2023 Aug 16;480(15):1183-1197. doi: 10.1042/BCJ20230129. Biochem J. 2023. PMID: 37401534

4

Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.

Hinchliffe P, Calvopiña K, Rabe P, Mojica MF, Schofield CJ, Dmitrienko GI, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: schofield cj. J Biol Chem. 2023 May;299(5):104606. doi: 10.1016/j.jbc.2023.104606. Epub 2023 Mar 15. J Biol Chem. 2023. PMID: 36924941 Free PMC article.

5

The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia.

Lawson H, Holt-Martyn JP, Dembitz V, Kabayama Y, Wang LM, Bellani A, Atwal S, Saffoon N, Durko J, van de Lagemaat LN, De Pace AL, Tumber A, Corner T, Salah E, Arndt C, Brewitz L, Bowen M, Dubusse L, George D, Allen L, Guitart AV, Fung TK, So CWE, Schwaller J, Gallipoli P, O'Carroll D, Schofield CJ, Kranc KR. Lawson H, et al. Among authors: schofield cj. Nat Cancer. 2024 Apr 18. doi: 10.1038/s43018-024-00761-w. Online ahead of print. Nat Cancer. 2024. PMID: 38637657

6

Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer-drug Kinetics.

Herold RA, Schofield CJ, Armstrong FA. Herold RA, et al. Among authors: schofield cj. Angew Chem Weinheim Bergstr Ger. 2023 Oct 16;135(42):e202309149. doi: 10.1002/ange.202309149. Epub 2023 Sep 12. Angew Chem Weinheim Bergstr Ger. 2023. PMID: 38529044 Free PMC article.

7

Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH.

Krishnan A, Waheed SO, Varghese A, Cherilakkudy FH, Schofield CJ, Karabencheva-Christova TG. Krishnan A, et al. Among authors: schofield cj. Chem Sci. 2024 Feb 5;15(10):3466-3484. doi: 10.1039/d3sc05974j. eCollection 2024 Mar 6. Chem Sci. 2024. PMID: 38455014 Free PMC article.

8

Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism.

John T, Saffoon N, Walsby-Tickle J, Hester SS, Dingler FA, Millington CL, McCullagh JSO, Patel KJ, Hopkinson RJ, Schofield CJ. John T, et al. Among authors: schofield cj. Chem Sci. 2024 Jan 15;15(7):2509-2517. doi: 10.1039/d3sc06551k. eCollection 2024 Feb 14. Chem Sci. 2024. PMID: 38362406 Free PMC article.

9

Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein.

Chan HTH, Brewitz L, Lukacik P, Strain-Damerell C, Walsh MA, Schofield CJ, Duarte F. Chan HTH, et al. Among authors: schofield cj. RSC Chem Biol. 2023 Oct 24;5(2):117-130. doi: 10.1039/d3cb00128h. eCollection 2024 Feb 7. RSC Chem Biol. 2023. PMID: 38333195 Free PMC article.

10

Biochemistry of the hypoxia-inducible factor hydroxylases.

Fiorini G, Schofield CJ. Fiorini G, et al. Among authors: schofield cj. Curr Opin Chem Biol. 2024 Apr;79:102428. doi: 10.1016/j.cbpa.2024.102428. Epub 2024 Feb 7. Curr Opin Chem Biol. 2024. PMID: 38330792 Free article. Review.

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