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706 results

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Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6.
Cockman ME, Sugimoto Y, Pegg HB, Masson N, Salah E, Tumber A, Flynn HR, Kirkpatrick JM, Schofield CJ, Ratcliffe PJ. Cockman ME, et al. Among authors: schofield cj. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2201483119. doi: 10.1073/pnas.2201483119. Epub 2022 Aug 5. Proc Natl Acad Sci U S A. 2022. PMID: 35930668 Free PMC article.
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. Epstein AC, et al. Among authors: schofield cj. Cell. 2001 Oct 5;107(1):43-54. doi: 10.1016/s0092-8674(01)00507-4. Cell. 2001. PMID: 11595184 Free article.
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. McNeill LA, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50. doi: 10.1016/s0960-894x(02)00219-6. Bioorg Med Chem Lett. 2002. PMID: 12039559
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ. Hewitson KS, et al. Among authors: schofield cj. J Biol Chem. 2002 Jul 19;277(29):26351-5. doi: 10.1074/jbc.C200273200. Epub 2002 May 31. J Biol Chem. 2002. PMID: 12042299 Free article.
2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Mole DR, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2677-80. doi: 10.1016/s0960-894x(03)00539-0. Bioorg Med Chem Lett. 2003. PMID: 12873492
Oxygen sensing by HIF hydroxylases.
Schofield CJ, Ratcliffe PJ. Schofield CJ, et al. Nat Rev Mol Cell Biol. 2004 May;5(5):343-54. doi: 10.1038/nrm1366. Nat Rev Mol Cell Biol. 2004. PMID: 15122348 Review. No abstract available.
706 results