Schofield CJ - Search Results

1

High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.

Newman H, Krajnc A, Bellini D, Eyermann CJ, Boyle GA, Paterson NG, McAuley KE, Lesniak R, Gangar M, von Delft F, Brem J, Chibale K, Schofield CJ, Dowson CG. Newman H, et al. Among authors: schofield cj. J Med Chem. 2021 Aug 12;64(15):11379-11394. doi: 10.1021/acs.jmedchem.1c00717. Epub 2021 Jul 31. J Med Chem. 2021. PMID: 34337941 Free PMC article.

2

A prodrug system for hydroxylamines based on esterase catalysis.

Conejo-Garcia A, Schofield CJ. Conejo-Garcia A, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4004-9. doi: 10.1016/j.bmcl.2005.06.026. Bioorg Med Chem Lett. 2005. PMID: 15990293

3

Inhibitors of the FEZ-1 metallo-beta-lactamase.

Liénard BM, Horsfall LE, Galleni M, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2007 Feb 15;17(4):964-8. doi: 10.1016/j.bmcl.2006.11.053. Epub 2006 Nov 18. Bioorg Med Chem Lett. 2007. PMID: 17157014

4

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Ng SS, et al. Among authors: schofield cj. Nature. 2007 Jul 5;448(7149):87-91. doi: 10.1038/nature05971. Epub 2007 Jun 24. Nature. 2007. PMID: 17589501

5

Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.

Liénard BM, Hüting R, Lassaux P, Galleni M, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: schofield cj. J Med Chem. 2008 Feb 14;51(3):684-8. doi: 10.1021/jm070866g. Epub 2008 Jan 19. J Med Chem. 2008. PMID: 18205296

6

Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.

Liénard BM, Garau G, Horsfall L, Karsisiotis AI, Damblon C, Lassaux P, Papamicael C, Roberts GC, Galleni M, Dideberg O, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: schofield cj. Org Biomol Chem. 2008 Jul 7;6(13):2282-94. doi: 10.1039/b802311e. Epub 2008 May 7. Org Biomol Chem. 2008. PMID: 18563261

7

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Rose NR, et al. Among authors: schofield cj. J Med Chem. 2008 Nov 27;51(22):7053-6. doi: 10.1021/jm800936s. J Med Chem. 2008. PMID: 18942826

8

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

Stubbs CJ, Loenarz C, Mecinović J, Yeoh KK, Hindley N, Liénard BM, Sobott F, Schofield CJ, Flashman E. Stubbs CJ, et al. Among authors: schofield cj. J Med Chem. 2009 May 14;52(9):2799-805. doi: 10.1021/jm900285r. J Med Chem. 2009. PMID: 19364117

9

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

Inglis SR, Zervosen A, Woon EC, Gerards T, Teller N, Fischer DS, Luxen A, Schofield CJ. Inglis SR, et al. Among authors: schofield cj. J Med Chem. 2009 Oct 8;52(19):6097-106. doi: 10.1021/jm9009718. J Med Chem. 2009. PMID: 19731939

10

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.

Mecinović J, Loenarz C, Chowdhury R, Schofield CJ. Mecinović J, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6192-5. doi: 10.1016/j.bmcl.2009.09.005. Epub 2009 Sep 6. Bioorg Med Chem Lett. 2009. PMID: 19775891

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