Schofield CJ - Search Results

1

The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases.

Roatsch M, Hoffmann I, Abboud MI, Hancock RL, Tarhonskaya H, Hsu KF, Wilkins SE, Yeh TL, Lippl K, Serrer K, Moneke I, Ahrens TD, Robaa D, Wenzler S, Barthes NPF, Franz H, Sippl W, Lassmann S, Diederichs S, Schleicher E, Schofield CJ, Kawamura A, Schüle R, Jung M. Roatsch M, et al. Among authors: schofield cj. ACS Chem Biol. 2019 Aug 16;14(8):1737-1750. doi: 10.1021/acschembio.9b00289. Epub 2019 Jul 19. ACS Chem Biol. 2019. PMID: 31287655

2

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Rose NR, et al. Among authors: schofield cj. J Med Chem. 2008 Nov 27;51(22):7053-6. doi: 10.1021/jm800936s. J Med Chem. 2008. PMID: 18942826

3

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).

Sekirnik R, Rose NR, Thalhammer A, Seden PT, Mecinović J, Schofield CJ. Sekirnik R, et al. Among authors: schofield cj. Chem Commun (Camb). 2009 Nov 14;(42):6376-8. doi: 10.1039/b916357c. Epub 2009 Sep 28. Chem Commun (Camb). 2009. PMID: 19841782

4

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Rose NR, et al. Among authors: schofield cj. J Med Chem. 2010 Feb 25;53(4):1810-8. doi: 10.1021/jm901680b. J Med Chem. 2010. PMID: 20088513 Free PMC article.

5

Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde.

Hopkinson RJ, Hamed RB, Rose NR, Claridge TD, Schofield CJ. Hopkinson RJ, et al. Among authors: schofield cj. Chembiochem. 2010 Mar 1;11(4):506-10. doi: 10.1002/cbic.200900713. Chembiochem. 2010. PMID: 20095001 No abstract available.

6

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield C. Kawamura A, et al. Anal Biochem. 2010 Sep 1;404(1):86-93. doi: 10.1016/j.ab.2010.04.030. Epub 2010 May 21. Anal Biochem. 2010. PMID: 20435012 Free PMC article.

7

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.

Mantri M, Krojer T, Bagg EA, Webby CJ, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ. Mantri M, et al. Among authors: schofield cj. J Mol Biol. 2010 Aug 13;401(2):211-22. J Mol Biol. 2010. PMID: 20684070

8

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Thalhammer A, Mecinović J, Loenarz C, Tumber A, Rose NR, Heightman TD, Schofield CJ. Thalhammer A, et al. Among authors: schofield cj. Org Biomol Chem. 2011 Jan 7;9(1):127-35. doi: 10.1039/c0ob00592d. Epub 2010 Nov 15. Org Biomol Chem. 2011. PMID: 21076780 Free PMC article.

9

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A. King ON, et al. Among authors: schofield cj. PLoS One. 2010 Nov 23;5(11):e15535. doi: 10.1371/journal.pone.0015535. PLoS One. 2010. PMID: 21124847 Free PMC article.

10

Inhibition of 2-oxoglutarate dependent oxygenases.

Rose NR, McDonough MA, King ON, Kawamura A, Schofield CJ. Rose NR, et al. Among authors: schofield cj. Chem Soc Rev. 2011 Aug;40(8):4364-97. doi: 10.1039/c0cs00203h. Epub 2011 Mar 10. Chem Soc Rev. 2011. PMID: 21390379 Review.

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