Schofield CJ - Search Results

1

Assay platform for clinically relevant metallo-β-lactamases.

van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. van Berkel SS, et al. Among authors: schofield cj. J Med Chem. 2013 Sep 12;56(17):6945-53. doi: 10.1021/jm400769b. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23898798 Free PMC article.

2

Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin.

Wright PA, Rostom AA, Robinson CV, Schofield CJ. Wright PA, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1219-21. doi: 10.1016/s0960-894x(00)00194-3. Bioorg Med Chem Lett. 2000. PMID: 10866385

3

Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-coenzyme A.

Kershaw NJ, Mukherji M, MacKinnon CH, Claridge TD, Odell B, Wierzbicki AS, Lloyd MD, Schofield CJ. Kershaw NJ, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2545-8. doi: 10.1016/s0960-894x(01)00494-2. Bioorg Med Chem Lett. 2001. PMID: 11549466

4

Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies.

Mollard C, Moali C, Papamicael C, Damblon C, Vessilier S, Amicosante G, Schofield CJ, Galleni M, Frere JM, Roberts GC. Mollard C, et al. Among authors: schofield cj. J Biol Chem. 2001 Nov 30;276(48):45015-23. doi: 10.1074/jbc.M107054200. Epub 2001 Sep 19. J Biol Chem. 2001. PMID: 11564740 Free article.

5

Enzymatic synthesis of monocyclic beta-lactams.

Sleeman MC, MacKinnon CH, Hewitson KS, Schofield CJ. Sleeman MC, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2002 Feb 25;12(4):597-9. doi: 10.1016/s0960-894x(01)00806-x. Bioorg Med Chem Lett. 2002. PMID: 11844680

6

Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.

Seibel J, Brown D, Amour A, Macdonald SJ, Oldham NJ, Schofield CJ. Seibel J, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2003 Feb 10;13(3):387-9. doi: 10.1016/s0960-894x(02)00995-2. Bioorg Med Chem Lett. 2003. PMID: 12565935

7

The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding.

Damblon C, Jensen M, Ababou A, Barsukov I, Papamicael C, Schofield CJ, Olsen L, Bauer R, Roberts GC. Damblon C, et al. Among authors: schofield cj. J Biol Chem. 2003 Aug 1;278(31):29240-51. doi: 10.1074/jbc.M301562200. Epub 2003 Apr 29. J Biol Chem. 2003. PMID: 12724330 Free article.

8

A prodrug system for hydroxylamines based on esterase catalysis.

Conejo-Garcia A, Schofield CJ. Conejo-Garcia A, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4004-9. doi: 10.1016/j.bmcl.2005.06.026. Bioorg Med Chem Lett. 2005. PMID: 15990293

9

Inhibitors of the FEZ-1 metallo-beta-lactamase.

Liénard BM, Horsfall LE, Galleni M, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2007 Feb 15;17(4):964-8. doi: 10.1016/j.bmcl.2006.11.053. Epub 2006 Nov 18. Bioorg Med Chem Lett. 2007. PMID: 17157014

10

Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.

Liénard BM, Hüting R, Lassaux P, Galleni M, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: schofield cj. J Med Chem. 2008 Feb 14;51(3):684-8. doi: 10.1021/jm070866g. Epub 2008 Jan 19. J Med Chem. 2008. PMID: 18205296

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