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Accelerating antiviral drug discovery: lessons from COVID-19.
von Delft A, Hall MD, Kwong AD, Purcell LA, Saikatendu KS, Schmitz U, Tallarico JA, Lee AA. von Delft A, et al. Among authors: schmitz u. Nat Rev Drug Discov. 2023 Jul;22(7):585-603. doi: 10.1038/s41573-023-00692-8. Epub 2023 May 12. Nat Rev Drug Discov. 2023. PMID: 37173515 Free PMC article. Review.
Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors.
Inniss NL, Kozic J, Li F, Rosas-Lemus M, Minasov G, Rybáček J, Zhu Y, Pohl R, Shuvalova L, Rulíšek L, Brunzelle JS, Bednárová L, Štefek M, Kormaník JM, Andris E, Šebestík J, Li ASM, Brown PJ, Schmitz U, Saikatendu K, Chang E, Nencka R, Vedadi M, Satchell KJF. Inniss NL, et al. Among authors: schmitz u. ACS Infect Dis. 2023 Oct 13;9(10):1918-1931. doi: 10.1021/acsinfecdis.3c00203. Epub 2023 Sep 20. ACS Infect Dis. 2023. PMID: 37728236 Free PMC article.
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Mulato A, Lansdon E, Aoyama R, Voigt J, Lee M, Liclican A, Lee G, Singer E, Stafford B, Gong R, Murray B, Chan J, Lee J, Xu Y, Ahmadyar S, Gonzalez A, Cho A, Stepan GJ, Schmitz U, Schultz B, Marchand B, Brumshtein B, Wang R, Yu H, Cihlar T, Xu L, Yant SR. Mulato A, et al. Among authors: schmitz u. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0137323. doi: 10.1128/aac.01373-23. Epub 2024 Feb 21. Antimicrob Agents Chemother. 2024. PMID: 38380945 Free PMC article.
Identifying cancer driver genes in individual tumours.
Gillman R, Field MA, Schmitz U, Karamatic R, Hebbard L. Gillman R, et al. Among authors: schmitz u. Comput Struct Biotechnol J. 2023 Oct 13;21:5028-5038. doi: 10.1016/j.csbj.2023.10.019. eCollection 2023. Comput Struct Biotechnol J. 2023. PMID: 37867967 Free PMC article. Review.
The application of long-read sequencing in clinical settings.
Oehler JB, Wright H, Stark Z, Mallett AJ, Schmitz U. Oehler JB, et al. Among authors: schmitz u. Hum Genomics. 2023 Aug 8;17(1):73. doi: 10.1186/s40246-023-00522-3. Hum Genomics. 2023. PMID: 37553611 Free PMC article. Review.
A signal-seeking Phase 2 study of olaparib and durvalumab in advanced solid cancers with homologous recombination repair gene alterations.
Thavaneswaran S, Kansara M, Lin F, Espinoza D, Grady JP, Lee CK, Ballinger ML, Sebastian L, Corpuz T, Qiu MR, Mundra P, Bailey CG, Schmitz U, Simes J, Joshua AM, Thomas DM. Thavaneswaran S, et al. Among authors: schmitz u. Br J Cancer. 2023 Aug;129(3):475-485. doi: 10.1038/s41416-023-02311-0. Epub 2023 Jun 26. Br J Cancer. 2023. PMID: 37365284 Free PMC article. Clinical Trial.
200 results