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Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
Carzaniga L, Linney ID, Rizzi A, Delcanale M, Schmidt W, Knight CK, Pastore F, Miglietta D, Carnini C, Cesari N, Riccardi B, Mileo V, Venturi L, Moretti E, Blackaby WP, Patacchini R, Accetta A, Biagetti M, Bassani F, Tondelli M, Murgo A, Battipaglia L, Villetti G, Puccini P, Catinella S, Civelli M, Rancati F. Carzaniga L, et al. Among authors: schmidt w. J Med Chem. 2022 Aug 11;65(15):10233-10250. doi: 10.1021/acs.jmedchem.2c00609. Epub 2022 Jul 28. J Med Chem. 2022. PMID: 35901125
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
Rancati F, Linney ID, Rizzi A, Delcanale M, Knight CK, Schmidt W, Pastore F, Riccardi B, Mileo V, Carnini C, Cesari N, Blackaby WP, Patacchini R, Carzaniga L. Rancati F, et al. Among authors: schmidt w. Bioorg Med Chem Lett. 2021 Jun 1;41:127975. doi: 10.1016/j.bmcl.2021.127975. Epub 2021 Mar 19. Bioorg Med Chem Lett. 2021. PMID: 33753262
Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis.
Andrews MJ, Clase JA, Bar G, Tricarico G, Edwards PJ, Brys R, Chambers M, Schmidt W, MacLeod A, Hirst K, Allen V, Birault V, Le J, Harris J, Self A, Nash K, Dixon G. Andrews MJ, et al. Among authors: schmidt w. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2266-70. doi: 10.1016/j.bmcl.2012.01.077. Epub 2012 Jan 31. Bioorg Med Chem Lett. 2012. PMID: 22342143
[Recommendations for defining giant cell arteritis fast-track clinics].
Schmidt WA, Czihal M, Gernert M, Hartung W, Hellmich B, Ohrndorf S, Riemekasten G, Schäfer VS, Strunk J, Venhoff N. Schmidt WA, et al. Z Rheumatol. 2024 May 8. doi: 10.1007/s00393-024-01519-6. Online ahead of print. Z Rheumatol. 2024. PMID: 38717506 German.
Widespread breakdown in masting in European beech due to rising summer temperatures.
Foest JJ, Bogdziewicz M, Pesendorfer MB, Ascoli D, Cutini A, Nussbaumer A, Verstraeten A, Beudert B, Chianucci F, Mezzavilla F, Gratzer G, Kunstler G, Meesenburg H, Wagner M, Mund M, Cools N, Vacek S, Schmidt W, Vacek Z, Hacket-Pain A. Foest JJ, et al. Among authors: schmidt w. Glob Chang Biol. 2024 May;30(5):e17307. doi: 10.1111/gcb.17307. Glob Chang Biol. 2024. PMID: 38709196
3,495 results