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The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress.
Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Müller MB, Schmidt MV. Hartmann J, et al. Among authors: schmidt u, schmidt mv. Neuropharmacology. 2012 Jan;62(1):332-9. doi: 10.1016/j.neuropharm.2011.07.041. Epub 2011 Aug 4. Neuropharmacology. 2012. PMID: 21839098
FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior.
Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Büll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, Cox MB, Schmidt U, Rein T. Touma C, et al. Among authors: schmidt u, schmidt mv. Biol Psychiatry. 2011 Nov 15;70(10):928-36. doi: 10.1016/j.biopsych.2011.07.023. Epub 2011 Sep 10. Biol Psychiatry. 2011. PMID: 21907973
The prospect of FKBP51 as a drug target.
Schmidt MV, Paez-Pereda M, Holsboer F, Hausch F. Schmidt MV, et al. ChemMedChem. 2012 Aug;7(8):1351-9. doi: 10.1002/cmdc.201200137. Epub 2012 May 13. ChemMedChem. 2012. PMID: 22581765
Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice.
Hartmann J, Wagner KV, Dedic N, Marinescu D, Scharf SH, Wang XD, Deussing JM, Hausch F, Rein T, Schmidt U, Holsboer F, Müller MB, Schmidt MV. Hartmann J, et al. Among authors: schmidt u, schmidt mv. Psychoneuroendocrinology. 2012 Dec;37(12):2009-21. doi: 10.1016/j.psyneuen.2012.04.017. Epub 2012 May 27. Psychoneuroendocrinology. 2012. PMID: 22641006
A polymorphism in the Crhr1 gene determines stress vulnerability in male mice.
Labermaier C, Kohl C, Hartmann J, Devigny C, Altmann A, Weber P, Arloth J, Quast C, Wagner KV, Scharf SH, Czibere L, Widner-Andrä R, Brenndörfer J, Landgraf R, Hausch F, Jones KA, Müller MB, Uhr M, Holsboer F, Binder EB, Schmidt MV. Labermaier C, et al. Among authors: schmidt mv. Endocrinology. 2014 Jul;155(7):2500-10. doi: 10.1210/en.2013-1986. Epub 2014 Apr 28. Endocrinology. 2014. PMID: 24773341
Selective inhibitors of the FK506-binding protein 51 by induced fit.
Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Fernandez-Vizarra P, Sippel C, Zannas AS, Draenert R, Binder EB, Almeida OF, Rühter G, Uhr M, Schmidt MV, Touma C, Bracher A, Hausch F. Gaali S, et al. Among authors: schmidt mv. Nat Chem Biol. 2015 Jan;11(1):33-7. doi: 10.1038/nchembio.1699. Epub 2014 Dec 1. Nat Chem Biol. 2015. PMID: 25436518
Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties.
Hartmann J, Wagner KV, Gaali S, Kirschner A, Kozany C, Rühter G, Dedic N, Häusl AS, Hoeijmakers L, Westerholz S, Namendorf C, Gerlach T, Uhr M, Chen A, Deussing JM, Holsboer F, Hausch F, Schmidt MV. Hartmann J, et al. Among authors: schmidt mv. J Neurosci. 2015 Jun 17;35(24):9007-16. doi: 10.1523/JNEUROSCI.4024-14.2015. J Neurosci. 2015. PMID: 26085626 Free PMC article.
167 results