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Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling.
Rosenberg N, Van Haele M, Lanton T, Brashi N, Bromberg Z, Adler H, Giladi H, Peled A, Goldenberg DS, Axelrod JH, Simerzin A, Chai C, Paldor M, Markezana A, Yaish D, Shemulian Z, Gross D, Barnoy S, Gefen M, Amran O, Claerhout S, Fernández-Vaquero M, García-Beccaria M, Heide D, Shoshkes-Carmel M, Schmidt Arras D, Elgavish S, Nevo Y, Benyamini H, Tirnitz-Parker JEE, Sanchez A, Herrera B, Safadi R, Kaestner KH, Rose-John S, Roskams T, Heikenwalder M, Galun E. Rosenberg N, et al. Among authors: schmidt arras d. J Hepatol. 2022 Dec;77(6):1631-1641. doi: 10.1016/j.jhep.2022.07.029. Epub 2022 Aug 18. J Hepatol. 2022. PMID: 35988690
The pro- and anti-inflammatory properties of the cytokine interleukin-6.
Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. Scheller J, et al. Among authors: schmidt arras d. Biochim Biophys Acta. 2011 May;1813(5):878-88. doi: 10.1016/j.bbamcr.2011.01.034. Epub 2011 Feb 4. Biochim Biophys Acta. 2011. PMID: 21296109 Free article. Review.
gp130 activation is regulated by D2-D3 interdomain connectivity.
Schütt A, Zacharias M, Schneider N, Horn S, Grötzinger J, Rose-John S, Schmidt-Arras D. Schütt A, et al. Among authors: schmidt arras d. Biochem J. 2013 Mar 15;450(3):487-96. doi: 10.1042/BJ20121660. Biochem J. 2013. PMID: 23294003
Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.
Schwarz J, Schmidt S, Will O, Koudelka T, Köhler K, Boss M, Rabe B, Tholey A, Scheller J, Schmidt-Arras D, Schwake M, Rose-John S, Chalaris A. Schwarz J, et al. Among authors: schmidt s, schmidt arras d. J Biol Chem. 2014 Jan 31;289(5):3080-93. doi: 10.1074/jbc.M113.536847. Epub 2013 Dec 13. J Biol Chem. 2014. PMID: 24338472 Free PMC article.
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis.
Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D. Müller M, et al. Among authors: schmidt arras d. Oncotarget. 2016 Apr 5;7(14):17431-41. doi: 10.18632/oncotarget.7836. Oncotarget. 2016. PMID: 26942887 Free PMC article.
IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.
Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mittrücker HW, Rose-John S, Schmidt-Arras D. Bergmann J, et al. Among authors: schmidt arras d. Hepatology. 2017 Jan;65(1):89-103. doi: 10.1002/hep.28874. Epub 2016 Nov 22. Hepatology. 2017. PMID: 27770462
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