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Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria.
Foss S, Sakya SA, Aguinagalde L, Lustig M, Shaughnessy J, Cruz AR, Scheepmaker L, Mathiesen L, Ruso-Julve F, Anthi AK, Gjølberg TT, Mester S, Bern M, Evers M, Bratlie DB, Michaelsen TE, Schlothauer T, Sok D, Bhattacharya J, Leusen J, Valerius T, Ram S, Rooijakkers SHM, Sandlie I, Andersen JT. Foss S, et al. Among authors: schlothauer t. Nat Commun. 2024 Mar 7;15(1):2007. doi: 10.1038/s41467-024-46321-9. Nat Commun. 2024. PMID: 38453922 Free PMC article.
Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans.
Grimm HP, Schumacher V, Schäfer M, Imhof-Jung S, Freskgård PO, Brady K, Hofmann C, Rüger P, Schlothauer T, Göpfert U, Hartl M, Rottach S, Zwick A, Seger S, Neff R, Niewoehner J, Janssen N. Grimm HP, et al. Among authors: schlothauer t. MAbs. 2023 Jan-Dec;15(1):2261509. doi: 10.1080/19420862.2023.2261509. Epub 2023 Oct 12. MAbs. 2023. PMID: 37823690 Free PMC article.
Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes.
Lippold S, Mistry K, Lenka S, Whang K, Liu P, Pitschi S, Kuhne F, Reusch D, Cadang L, Knaupp A, Izadi S, Dunkle A, Yang F, Schlothauer T. Lippold S, et al. Among authors: schlothauer t. Front Immunol. 2023 Sep 18;14:1260446. doi: 10.3389/fimmu.2023.1260446. eCollection 2023. Front Immunol. 2023. PMID: 37790943 Free PMC article.
CD3 Target Affinity Chromatography Mass Spectrometry as a New Tool for Function-Structure Characterization of T-Cell Engaging Bispecific Antibody Proteoforms and Product-Related Variants.
Lippold S, Hook M, Spick C, Knaupp A, Whang K, Ruperti F, Cadang L, Andersen N, Vogt A, Grote M, Reusch D, Haberger M, Yang F, Schlothauer T. Lippold S, et al. Among authors: schlothauer t. Anal Chem. 2023 Jan 31;95(4):2260-2268. doi: 10.1021/acs.analchem.2c03827. Epub 2023 Jan 13. Anal Chem. 2023. PMID: 36638115
46 results