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L-arginine metabolism inhibits arthritis and inflammatory bone loss.
Cao S, Li Y, Song R, Meng X, Fuchs M, Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, Taudte V, Gessner A, Kunz M, Schleicher U, Zaiss MM, Kastbom A, Chen X, Schett G, Bozec A. Cao S, et al. Among authors: schleicher u. Ann Rheum Dis. 2024 Jan 2;83(1):72-87. doi: 10.1136/ard-2022-223626. Ann Rheum Dis. 2024. PMID: 37775153 Free PMC article.
Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis.
Hannemann N, Cao S, Eriksson D, Schnelzer A, Jordan J, Eberhardt M, Schleicher U, Rech J, Ramming A, Uebe S, Ekici A, Cañete JD, Chen X, Bäuerle T, Vera J, Bogdan C, Schett G, Bozec A. Hannemann N, et al. Among authors: schleicher u. J Clin Invest. 2019 Apr 16;129(7):2669-2684. doi: 10.1172/JCI96832. J Clin Invest. 2019. PMID: 30990796 Free PMC article.
Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.
Kohl L, Siddique MNAA, Bodendorfer B, Berger R, Preikschat A, Daniel C, Ölke M, Liebler-Tenorio E, Schulze-Luehrmann J, Mauermeir M, Yang KT, Hayek I, Szperlinski M, Andrack J, Schleicher U, Bozec A, Krönke G, Murray PJ, Wirtz S, Yamamoto M, Schatz V, Jantsch J, Oefner P, Degrandi D, Pfeffer K, Mertens-Scholz K, Rauber S, Bogdan C, Dettmer K, Lührmann A, Lang R. Kohl L, et al. Among authors: schleicher u. EMBO Mol Med. 2023 Feb 8;15(2):e15931. doi: 10.15252/emmm.202215931. Epub 2022 Dec 7. EMBO Mol Med. 2023. PMID: 36479617 Free PMC article.
Cytokine-Mediated Regulation of ARG1 in Macrophages and Its Impact on the Control of Salmonella enterica Serovar Typhimurium Infection.
Brigo N, Pfeifhofer-Obermair C, Tymoszuk P, Demetz E, Engl S, Barros-Pinkelnig M, Dichtl S, Fischer C, Valente De Souza L, Petzer V, von Raffay L, Hilbe R, Berger S, Seifert M, Schleicher U, Bogdan C, Weiss G. Brigo N, et al. Among authors: schleicher u. Cells. 2021 Jul 19;10(7):1823. doi: 10.3390/cells10071823. Cells. 2021. PMID: 34359992 Free PMC article.
Arginase impedes the resolution of colitis by altering the microbiome and metabolome.
Baier J, Gänsbauer M, Giessler C, Arnold H, Muske M, Schleicher U, Lukassen S, Ekici A, Rauh M, Daniel C, Hartmann A, Schmid B, Tripal P, Dettmer K, Oefner PJ, Atreya R, Wirtz S, Bogdan C, Mattner J. Baier J, et al. Among authors: schleicher u. J Clin Invest. 2020 Nov 2;130(11):5703-5720. doi: 10.1172/JCI126923. J Clin Invest. 2020. PMID: 32721946 Free PMC article.
80 results