Schleicher EM - Search Results

1

Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling.

Thakar T, Dhoonmoon A, Straka J, Schleicher EM, Nicolae CM, Moldovan GL. Thakar T, et al. Among authors: schleicher em. Nat Commun. 2022 Sep 9;13(1):5323. doi: 10.1038/s41467-022-33028-y. Nat Commun. 2022. PMID: 36085347 Free PMC article.

2

Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens.

Clements KE, Schleicher EM, Thakar T, Hale A, Dhoonmoon A, Tolman NJ, Sharma A, Liang X, Imamura Kawasawa Y, Nicolae CM, Wang HG, De S, Moldovan GL. Clements KE, et al. Among authors: schleicher em. Nat Commun. 2020 Nov 30;11(1):6118. doi: 10.1038/s41467-020-19961-w. Nat Commun. 2020. PMID: 33257658 Free PMC article.

3

Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells.

Jackson LM, Dhoonmoon A, Hale A, Dennis KA, Schleicher EM, Nicolae CM, Moldovan GL. Jackson LM, et al. Among authors: schleicher em. Nucleic Acids Res. 2021 Dec 16;49(22):12855-12869. doi: 10.1093/nar/gkab1184. Nucleic Acids Res. 2021. PMID: 34871431 Free PMC article.

4

The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells.

Schleicher EM, Dhoonmoon A, Jackson LM, Khatib JB, Nicolae CM, Moldovan GL. Schleicher EM, et al. Oncogenesis. 2022 Jun 18;11(1):33. doi: 10.1038/s41389-022-00410-w. Oncogenesis. 2022. PMID: 35717336 Free PMC article.

5

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress.

Schleicher EM, Galvan AM, Imamura-Kawasawa Y, Moldovan GL, Nicolae CM. Schleicher EM, et al. Nucleic Acids Res. 2018 Sep 28;46(17):8908-8916. doi: 10.1093/nar/gky658. Nucleic Acids Res. 2018. PMID: 30032250 Free PMC article.

6

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR.

Dhoonmoon A, Schleicher EM, Clements KE, Nicolae CM, Moldovan GL. Dhoonmoon A, et al. Among authors: schleicher em. Nucleic Acids Res. 2020 Jul 27;48(13):7252-7264. doi: 10.1093/nar/gkaa508. Nucleic Acids Res. 2020. PMID: 32542389 Free PMC article.

7

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors.

Schleicher EM, Dhoonmoon A, Jackson LM, Clements KE, Stump CL, Nicolae CM, Moldovan GL. Schleicher EM, et al. PLoS Genet. 2020 Nov 2;16(11):e1009176. doi: 10.1371/journal.pgen.1009176. eCollection 2020 Nov. PLoS Genet. 2020. PMID: 33137164 Free PMC article.

8

CRISPR screens guide the way for PARP and ATR inhibitor biomarker discovery.

Schleicher EM, Moldovan GL. Schleicher EM, et al. FEBS J. 2022 Dec;289(24):7854-7868. doi: 10.1111/febs.16217. Epub 2021 Oct 17. FEBS J. 2022. PMID: 34601817 Free PMC article. Review.

9

Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival.

Khatib JB, Schleicher EM, Jackson LM, Dhoonmoon A, Moldovan GL, Nicolae CM. Khatib JB, et al. Among authors: schleicher em. Oncotarget. 2022 Sep 28;13:1078-1091. doi: 10.18632/oncotarget.28277. eCollection 2022. Oncotarget. 2022. PMID: 36187556 Free PMC article.

10

PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells.

Nicolae CM, O'Connor MJ, Schleicher EM, Song C, Gowda R, Robertson G, Dovat S, Moldovan GL. Nicolae CM, et al. Among authors: schleicher em. Oncogene. 2019 Jul;38(27):5530-5540. doi: 10.1038/s41388-019-0810-x. Epub 2019 Apr 9. Oncogene. 2019. PMID: 30967629

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