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Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity.
Hippen KL, Merkel SC, Schirm DK, Sieben CM, Sumstad D, Kadidlo DM, McKenna DH, Bromberg JS, Levine BL, Riley JL, June CH, Scheinberg P, Douek DC, Miller JS, Wagner JE, Blazar BR. Hippen KL, et al. Among authors: schirm dk. Sci Transl Med. 2011 May 18;3(83):83ra41. doi: 10.1126/scitranslmed.3001809. Sci Transl Med. 2011. PMID: 21593401 Free PMC article.
Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes.
Hippen KL, Bucher C, Schirm DK, Bearl AM, Brender T, Mink KA, Waggie KS, Peffault de Latour R, Janin A, Curtsinger JM, Dillon SR, Miller JS, Socie G, Blazar BR. Hippen KL, et al. Among authors: schirm dk. Blood. 2012 Jan 12;119(2):619-28. doi: 10.1182/blood-2011-07-368027. Epub 2011 Nov 10. Blood. 2012. PMID: 22077059 Free PMC article.
Potent Cytolytic Activity and Specific IL15 Delivery in a Second-Generation Trispecific Killer Engager.
Felices M, Lenvik TR, Kodal B, Lenvik AJ, Hinderlie P, Bendzick LE, Schirm DK, Kaminski MF, McElmurry RT, Geller MA, Eckfeldt CE, Vallera DA, Miller JS. Felices M, et al. Among authors: schirm dk. Cancer Immunol Res. 2020 Sep;8(9):1139-1149. doi: 10.1158/2326-6066.CIR-19-0837. Epub 2020 Jul 13. Cancer Immunol Res. 2020. PMID: 32661096 Free PMC article.
Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.
Pomeroy EJ, Lee LA, Lee RDW, Schirm DK, Temiz NA, Ma J, Gruber TA, Diaz-Flores E, Moriarity BS, Downing JR, Shannon KM, Largaespada DA, Eckfeldt CE. Pomeroy EJ, et al. Among authors: schirm dk. Oncogene. 2017 Jun 8;36(23):3263-3273. doi: 10.1038/onc.2016.471. Epub 2016 Dec 19. Oncogene. 2017. PMID: 27991934 Free PMC article.