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Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.
Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. Frost JL, et al. Among authors: schilling s. Am J Pathol. 2013 Aug;183(2):369-81. doi: 10.1016/j.ajpath.2013.05.005. Epub 2013 Jun 7. Am J Pathol. 2013. PMID: 23747948 Free PMC article.
Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice.
Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O'Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA. Crehan H, et al. Among authors: schilling s. Alzheimers Res Ther. 2020 Jan 13;12(1):12. doi: 10.1186/s13195-019-0579-8. Alzheimers Res Ther. 2020. PMID: 31931873 Free PMC article.
Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology.
Gnoth K, Piechotta A, Kleinschmidt M, Konrath S, Schenk M, Taudte N, Ramsbeck D, Rieckmann V, Geissler S, Eichentopf R, Barendrecht S, Hartlage-Rübsamen M, Demuth HU, Roßner S, Cynis H, Rahfeld JU, Schilling S. Gnoth K, et al. Among authors: schilling s. Alzheimers Res Ther. 2020 Nov 14;12(1):149. doi: 10.1186/s13195-020-00719-x. Alzheimers Res Ther. 2020. PMID: 33189132 Free PMC article.
Focused ultrasound with anti-pGlu3 Aβ enhances efficacy in Alzheimer's disease-like mice via recruitment of peripheral immune cells.
Sun T, Shi Q, Zhang Y, Power C, Hoesch C, Antonelli S, Schroeder MK, Caldarone BJ, Taudte N, Schenk M, Hettmann T, Schilling S, McDannold NJ, Lemere CA. Sun T, et al. Among authors: schilling s. J Control Release. 2021 Aug 10;336:443-456. doi: 10.1016/j.jconrel.2021.06.037. Epub 2021 Jun 26. J Control Release. 2021. PMID: 34186148 Free PMC article.
A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.
Hartlage-Rübsamen M, Bluhm A, Moceri S, Machner L, Köppen J, Schenk M, Hilbrich I, Holzer M, Weidenfeller M, Richter F, Coras R, Serrano GE, Beach TG, Schilling S, von Hörsten S, Xiang W, Schulze A, Roßner S. Hartlage-Rübsamen M, et al. Among authors: schilling s. Acta Neuropathol. 2021 Sep;142(3):399-421. doi: 10.1007/s00401-021-02349-5. Epub 2021 Jul 26. Acta Neuropathol. 2021. PMID: 34309760 Free PMC article.
356 results