Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M, Sierra NA, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD.
Mealka M, et al. Among authors: schiffer jm.
Nat Commun. 2024 May 6;15(1):3785. doi: 10.1038/s41467-024-48277-2.
Nat Commun. 2024.
PMID: 38710674
Free PMC article.