Schiffer CA - Search Results

1

Dual Inhibitors of Main Protease (M^Pro) and Cathepsin L as Potent Antivirals against SARS-CoV2.

Mondal S, Chen Y, Lockbaum GJ, Sen S, Chaudhuri S, Reyes AC, Lee JM, Kaur AN, Sultana N, Cameron MD, Shaffer SA, Schiffer CA, Fitzgerald KA, Thompson PR. Mondal S, et al. Among authors: schiffer ca. J Am Chem Soc. 2022 Nov 23;144(46):21035-21045. doi: 10.1021/jacs.2c04626. Epub 2022 Nov 10. J Am Chem Soc. 2022. PMID: 36356199 Free PMC article.

2

HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.

Altman MD, Ali A, Reddy GS, Nalam MN, Anjum SG, Cao H, Chellappan S, Kairys V, Fernandes MX, Gilson MK, Schiffer CA, Rana TM, Tidor B. Altman MD, et al. Among authors: schiffer ca. J Am Chem Soc. 2008 May 14;130(19):6099-113. doi: 10.1021/ja076558p. Epub 2008 Apr 16. J Am Chem Soc. 2008. PMID: 18412349 Free PMC article.

3

Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.

Chen W, Lam SS, Srinath H, Jiang Z, Correia JJ, Schiffer CA, Fitzgerald KA, Lin K, Royer WE Jr. Chen W, et al. Among authors: schiffer ca. Nat Struct Mol Biol. 2008 Nov;15(11):1213-20. doi: 10.1038/nsmb.1496. Epub 2008 Oct 5. Nat Struct Mol Biol. 2008. PMID: 18836453 Free PMC article.

4

Viral protease inhibitors.

Anderson J, Schiffer C, Lee SK, Swanstrom R. Anderson J, et al. Handb Exp Pharmacol. 2009;189(189):85-110. doi: 10.1007/978-3-540-79086-0_4. Handb Exp Pharmacol. 2009. PMID: 19048198 Free PMC article. Review.

5

Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease.

Mittal S, Cai Y, Nalam MN, Bolon DN, Schiffer CA. Mittal S, et al. Among authors: schiffer ca. J Am Chem Soc. 2012 Mar 7;134(9):4163-8. doi: 10.1021/ja2095766. Epub 2012 Feb 28. J Am Chem Soc. 2012. PMID: 22295904 Free PMC article.

6

Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.

King NM, Prabu-Jeyabalan M, Bandaranayake RM, Nalam MN, Nalivaika EA, Özen A, Haliloğlu T, Yilmaz NK, Schiffer CA. King NM, et al. Among authors: schiffer ca. ACS Chem Biol. 2012 Sep 21;7(9):1536-46. doi: 10.1021/cb300191k. Epub 2012 Jul 2. ACS Chem Biol. 2012. PMID: 22712830 Free PMC article.

7

The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.

Romano KP, Ali A, Aydin C, Soumana D, Ozen A, Deveau LM, Silver C, Cao H, Newton A, Petropoulos CJ, Huang W, Schiffer CA. Romano KP, et al. Among authors: schiffer ca. PLoS Pathog. 2012;8(7):e1002832. doi: 10.1371/journal.ppat.1002832. Epub 2012 Jul 26. PLoS Pathog. 2012. PMID: 22910833 Free PMC article.

8

Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.

Ali A, Aydin C, Gildemeister R, Romano KP, Cao H, Ozen A, Soumana D, Newton A, Petropoulos CJ, Huang W, Schiffer CA. Ali A, et al. Among authors: schiffer ca. ACS Chem Biol. 2013 Jul 19;8(7):1469-78. doi: 10.1021/cb400100g. Epub 2013 May 1. ACS Chem Biol. 2013. PMID: 23594083 Free PMC article.

9

Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.

Ragland DA, Nalivaika EA, Nalam MN, Prachanronarong KL, Cao H, Bandaranayake RM, Cai Y, Kurt-Yilmaz N, Schiffer CA. Ragland DA, et al. Among authors: schiffer ca. J Am Chem Soc. 2014 Aug 27;136(34):11956-63. doi: 10.1021/ja504096m. Epub 2014 Aug 18. J Am Chem Soc. 2014. PMID: 25091085 Free PMC article.

10

Structural analysis of asunaprevir resistance in HCV NS3/4A protease.

Soumana DI, Ali A, Schiffer CA. Soumana DI, et al. Among authors: schiffer ca. ACS Chem Biol. 2014 Nov 21;9(11):2485-90. doi: 10.1021/cb5006118. Epub 2014 Sep 30. ACS Chem Biol. 2014. PMID: 25243902 Free PMC article.

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