Schiffer CA - Search Results

1

Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes.

Cai EP, Ishikawa Y, Zhang W, Leite NC, Li J, Hou S, Kiaf B, Hollister-Lock J, Yilmaz NK, Schiffer CA, Melton DA, Kissler S, Yi P. Cai EP, et al. Among authors: schiffer ca. Nat Metab. 2020 Sep;2(9):934-945. doi: 10.1038/s42255-020-0254-1. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719542 Free PMC article.

2

Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.

King NM, Prabu-Jeyabalan M, Bandaranayake RM, Nalam MN, Nalivaika EA, Özen A, Haliloğlu T, Yilmaz NK, Schiffer CA. King NM, et al. Among authors: schiffer ca. ACS Chem Biol. 2012 Sep 21;7(9):1536-46. doi: 10.1021/cb300191k. Epub 2012 Jul 2. ACS Chem Biol. 2012. PMID: 22712830 Free PMC article.

3

Differential Flap Dynamics in Wild-type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation.

Cai Y, Yilmaz NK, Myint W, Ishima R, Schiffer CA. Cai Y, et al. Among authors: schiffer ca. J Chem Theory Comput. 2012 Oct 9;8(10):3452-3462. doi: 10.1021/ct300076y. Epub 2012 Apr 17. J Chem Theory Comput. 2012. PMID: 23144597 Free PMC article.

4

Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.

Mittal S, Bandaranayake RM, King NM, Prabu-Jeyabalan M, Nalam MN, Nalivaika EA, Yilmaz NK, Schiffer CA. Mittal S, et al. Among authors: schiffer ca. J Virol. 2013 Apr;87(8):4176-84. doi: 10.1128/JVI.03486-12. Epub 2013 Jan 30. J Virol. 2013. PMID: 23365446 Free PMC article.

5

Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.

Nalam MN, Ali A, Reddy GS, Cao H, Anjum SG, Altman MD, Yilmaz NK, Tidor B, Rana TM, Schiffer CA. Nalam MN, et al. Among authors: schiffer ca. Chem Biol. 2013 Sep 19;20(9):1116-24. doi: 10.1016/j.chembiol.2013.07.014. Epub 2013 Sep 5. Chem Biol. 2013. PMID: 24012370 Free PMC article.

6

Dengue Protease Substrate Recognition: Binding of the Prime Side.

Lin KH, Nalivaika EA, Prachanronarong KL, Yilmaz NK, Schiffer CA. Lin KH, et al. Among authors: schiffer ca. ACS Infect Dis. 2016 Oct 14;2(10):734-743. doi: 10.1021/acsinfecdis.6b00131. Epub 2016 Sep 22. ACS Infect Dis. 2016. PMID: 27657335 Free PMC article.

7

Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody.

Prachanronarong KL, Canale AS, Liu P, Somasundaran M, Hou S, Poh YP, Han T, Zhu Q, Renzette N, Zeldovich KB, Kowalik TF, Kurt-Yilmaz N, Jensen JD, Bolon DNA, Marasco WA, Finberg RW, Schiffer CA, Wang JP. Prachanronarong KL, et al. Among authors: schiffer ca. J Virol. 2019 Jan 4;93(2):e01639-18. doi: 10.1128/JVI.01639-18. Print 2019 Jan 15. J Virol. 2019. PMID: 30381484 Free PMC article.

8

Structural Analysis of the Active Site and DNA Binding of Human Cytidine Deaminase APOBEC3B.

Hou S, Silvas TV, Leidner F, Nalivaika EA, Matsuo H, Kurt Yilmaz N, Schiffer CA. Hou S, et al. Among authors: schiffer ca. J Chem Theory Comput. 2019 Jan 8;15(1):637-647. doi: 10.1021/acs.jctc.8b00545. Epub 2018 Dec 11. J Chem Theory Comput. 2019. PMID: 30457868 Free PMC article.

9

Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.

Lockbaum GJ, Leidner F, Rusere LN, Henes M, Kosovrasti K, Nachum GS, Nalivaika EA, Ali A, Yilmaz NK, Schiffer CA. Lockbaum GJ, et al. Among authors: schiffer ca. ACS Infect Dis. 2019 Feb 8;5(2):316-325. doi: 10.1021/acsinfecdis.8b00336. Epub 2018 Dec 31. ACS Infect Dis. 2019. PMID: 30543749 Free PMC article.

10

HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope.

Rusere LN, Lockbaum GJ, Lee SK, Henes M, Kosovrasti K, Spielvogel E, Nalivaika EA, Swanstrom R, Yilmaz NK, Schiffer CA, Ali A. Rusere LN, et al. Among authors: schiffer ca. J Med Chem. 2019 Sep 12;62(17):8062-8079. doi: 10.1021/acs.jmedchem.9b00838. Epub 2019 Aug 21. J Med Chem. 2019. PMID: 31386368 Free PMC article.

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