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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.
Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR. Fullerton MD, et al. Among authors: schertzer jd. Nat Med. 2013 Dec;19(12):1649-54. doi: 10.1038/nm.3372. Epub 2013 Nov 3. Nat Med. 2013. PMID: 24185692 Free PMC article.
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation.
Dzamko N, Schertzer JD, Ryall JG, Steel R, Macaulay SL, Wee S, Chen ZP, Michell BJ, Oakhill JS, Watt MJ, Jørgensen SB, Lynch GS, Kemp BE, Steinberg GR. Dzamko N, et al. Among authors: schertzer jd. J Physiol. 2008 Dec 1;586(23):5819-31. doi: 10.1113/jphysiol.2008.159814. Epub 2008 Oct 9. J Physiol. 2008. PMID: 18845612 Free PMC article.
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.
Steinberg GR, O'Neill HM, Dzamko NL, Galic S, Naim T, Koopman R, Jørgensen SB, Honeyman J, Hewitt K, Chen ZP, Schertzer JD, Scott JW, Koentgen F, Lynch GS, Watt MJ, van Denderen BJ, Campbell DJ, Kemp BE. Steinberg GR, et al. Among authors: schertzer jd. J Biol Chem. 2010 Nov 26;285(48):37198-209. doi: 10.1074/jbc.M110.102434. Epub 2010 Sep 20. J Biol Chem. 2010. PMID: 20855892 Free PMC article.
NOD1 activators link innate immunity to insulin resistance.
Schertzer JD, Tamrakar AK, Magalhães JG, Pereira S, Bilan PJ, Fullerton MD, Liu Z, Steinberg GR, Giacca A, Philpott DJ, Klip A. Schertzer JD, et al. Diabetes. 2011 Sep;60(9):2206-15. doi: 10.2337/db11-0004. Epub 2011 Jun 29. Diabetes. 2011. PMID: 21715553 Free PMC article.
AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.
O'Neill HM, Maarbjerg SJ, Crane JD, Jeppesen J, Jørgensen SB, Schertzer JD, Shyroka O, Kiens B, van Denderen BJ, Tarnopolsky MA, Kemp BE, Richter EA, Steinberg GR. O'Neill HM, et al. Among authors: schertzer jd. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16092-7. doi: 10.1073/pnas.1105062108. Epub 2011 Sep 6. Proc Natl Acad Sci U S A. 2011. PMID: 21896769 Free PMC article.
Immunometabolism of AMPK in insulin resistance and atherosclerosis.
Fullerton MD, Steinberg GR, Schertzer JD. Fullerton MD, et al. Among authors: schertzer jd. Mol Cell Endocrinol. 2013 Feb 25;366(2):224-34. doi: 10.1016/j.mce.2012.02.004. Epub 2012 Feb 14. Mol Cell Endocrinol. 2013. PMID: 22361321 Review.
The ancient drug salicylate directly activates AMP-activated protein kinase.
Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG. Hawley SA, et al. Among authors: schertzer jd. Science. 2012 May 18;336(6083):918-22. doi: 10.1126/science.1215327. Epub 2012 Apr 19. Science. 2012. PMID: 22517326 Free PMC article.
Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity.
Jorgensen SB, O'Neill HM, Sylow L, Honeyman J, Hewitt KA, Palanivel R, Fullerton MD, Öberg L, Balendran A, Galic S, van der Poel C, Trounce IA, Lynch GS, Schertzer JD, Steinberg GR. Jorgensen SB, et al. Among authors: schertzer jd. Diabetes. 2013 Jan;62(1):56-64. doi: 10.2337/db12-0443. Epub 2012 Sep 6. Diabetes. 2013. PMID: 22961088 Free PMC article.
136 results