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Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase.
Thöny B, Calvo AC, Scherer T, Svebak RM, Haavik J, Blau N, Martinez A. Thöny B, et al. Among authors: scherer t. J Neurochem. 2008 Jul;106(2):672-81. doi: 10.1111/j.1471-4159.2008.05423.x. Epub 2008 Apr 14. J Neurochem. 2008. PMID: 18419768 Free article.
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.
Korner G, Noain D, Ying M, Hole M, Flydal MI, Scherer T, Allegri G, Rassi A, Fingerhut R, Becu-Villalobos D, Pillai S, Wueest S, Konrad D, Lauber-Biason A, Baumann CR, Bindoff LA, Martinez A, Thöny B. Korner G, et al. Among authors: scherer t. Brain. 2015 Oct;138(Pt 10):2948-63. doi: 10.1093/brain/awv224. Epub 2015 Aug 14. Brain. 2015. PMID: 26276013 Free article.
Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
Korner G, Scherer T, Adamsen D, Rebuffat A, Crabtree M, Rassi A, Scavelli R, Homma D, Ledermann B, Konrad D, Ichinose H, Wolfrum C, Horsch M, Rathkolb B, Klingenspor M, Beckers J, Wolf E, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Blau N, Rozman J, Thöny B. Korner G, et al. Among authors: scherer t. J Inherit Metab Dis. 2016 Mar;39(2):309-19. doi: 10.1007/s10545-015-9909-6. Epub 2016 Feb 1. J Inherit Metab Dis. 2016. PMID: 26830550
Low-Dose Gene Therapy for Murine PKU Using Episomal Naked DNA Vectors Expressing PAH from Its Endogenous Liver Promoter.
Grisch-Chan HM, Schlegel A, Scherer T, Allegri G, Heidelberger R, Tsikrika P, Schmeer M, Schleef M, Harding CO, Häberle J, Thöny B. Grisch-Chan HM, et al. Among authors: scherer t. Mol Ther Nucleic Acids. 2017 Jun 16;7:339-349. doi: 10.1016/j.omtn.2017.04.013. Epub 2017 Apr 20. Mol Ther Nucleic Acids. 2017. PMID: 28624210 Free PMC article.
174 results