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Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.
Carraro F, Naldini A, Pucci A, Locatelli GA, Maga G, Schenone S, Bruno O, Ranise A, Bondavalli F, Brullo C, Fossa P, Menozzi G, Mosti L, Modugno M, Tintori C, Manetti F, Botta M. Carraro F, et al. Among authors: schenone s. J Med Chem. 2006 Mar 9;49(5):1549-61. doi: 10.1021/jm050603r. J Med Chem. 2006. PMID: 16509573
Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice.
Manetti F, Santucci A, Locatelli GA, Maga G, Spreafico A, Serchi T, Orlandini M, Bernardini G, Caradonna NP, Spallarossa A, Brullo C, Schenone S, Bruno O, Ranise A, Bondavalli F, Hoffmann O, Bologna M, Angelucci A, Botta M. Manetti F, et al. Among authors: schenone s. J Med Chem. 2007 Nov 15;50(23):5579-88. doi: 10.1021/jm061449r. Epub 2007 Oct 11. J Med Chem. 2007. PMID: 17929792
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines.
Manetti F, Brullo C, Magnani M, Mosci F, Chelli B, Crespan E, Schenone S, Naldini A, Bruno O, Trincavelli ML, Maga G, Carraro F, Martini C, Bondavalli F, Botta M. Manetti F, et al. Among authors: schenone s. J Med Chem. 2008 Mar 13;51(5):1252-9. doi: 10.1021/jm701240c. Epub 2008 Feb 8. J Med Chem. 2008. PMID: 18257513
A1 receptors ligands: past, present and future trends.
Schenone S, Brullo C, Musumeci F, Bruno O, Botta M. Schenone S, et al. Curr Top Med Chem. 2010;10(9):878-901. doi: 10.2174/156802610791268729. Curr Top Med Chem. 2010. PMID: 20370661 Review.
213 results