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Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity.
Hippen KL, Merkel SC, Schirm DK, Sieben CM, Sumstad D, Kadidlo DM, McKenna DH, Bromberg JS, Levine BL, Riley JL, June CH, Scheinberg P, Douek DC, Miller JS, Wagner JE, Blazar BR. Hippen KL, et al. Among authors: scheinberg p. Sci Transl Med. 2011 May 18;3(83):83ra41. doi: 10.1126/scitranslmed.3001809. Sci Transl Med. 2011. PMID: 21593401 Free PMC article.
CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo.
Hanley PJ, Melenhorst JJ, Nikiforow S, Scheinberg P, Blaney JW, Demmler-Harrison G, Cruz CR, Lam S, Krance RA, Leung KS, Martinez CA, Liu H, Douek DC, Heslop HE, Rooney CM, Shpall EJ, Barrett AJ, Rodgers JR, Bollard CM. Hanley PJ, et al. Among authors: scheinberg p. Sci Transl Med. 2015 Apr 29;7(285):285ra63. doi: 10.1126/scitranslmed.aaa2546. Sci Transl Med. 2015. PMID: 25925682 Free PMC article.
Alloreactivity across HLA barriers is mediated by both naïve and antigen-experienced T cells.
Melenhorst JJ, Scheinberg P, Williams A, Ambrozak DR, Keyvanfar K, Smith M, McCoy JP Jr, Hensel NF, Douek DC, Barrett AJ. Melenhorst JJ, et al. Among authors: scheinberg p. Biol Blood Marrow Transplant. 2011 Jun;17(6):800-9. doi: 10.1016/j.bbmt.2010.12.711. Epub 2011 Jan 6. Biol Blood Marrow Transplant. 2011. PMID: 21215812 Free PMC article.
The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor.
Scheinberg P, Melenhorst JJ, Brenchley JM, Hill BJ, Hensel NF, Chattopadhyay PK, Roederer M, Picker LJ, Price DA, Barrett AJ, Douek DC. Scheinberg P, et al. Blood. 2009 Dec 3;114(24):5071-80. doi: 10.1182/blood-2009-04-214684. Epub 2009 Sep 23. Blood. 2009. PMID: 19776383 Free PMC article.
249 results