Scheffzek K - Search Results

1

Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis.

McGillicuddy LT, Fromm JA, Hollstein PE, Kubek S, Beroukhim R, De Raedt T, Johnson BW, Williams SM, Nghiemphu P, Liau LM, Cloughesy TF, Mischel PS, Parret A, Seiler J, Moldenhauer G, Scheffzek K, Stemmer-Rachamimov AO, Sawyers CL, Brennan C, Messiaen L, Mellinghoff IK, Cichowski K. McGillicuddy LT, et al. Among authors: scheffzek k. Cancer Cell. 2009 Jul 7;16(1):44-54. doi: 10.1016/j.ccr.2009.05.009. Cancer Cell. 2009. PMID: 19573811 Free PMC article.

2

Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation.

Denayer E, Parret A, Chmara M, Schubbert S, Vogels A, Devriendt K, Frijns JP, Rybin V, de Ravel TJ, Shannon K, Cools J, Scheffzek K, Legius E. Denayer E, et al. Among authors: scheffzek k. Hum Mutat. 2008 Feb;29(2):232-9. doi: 10.1002/humu.20616. Hum Mutat. 2008. PMID: 17979197

3

Structural basis of activation of the tumor suppressor protein neurofibromin.

Chaker-Margot M, Werten S, Dunzendorfer-Matt T, Lechner S, Ruepp A, Scheffzek K, Maier T. Chaker-Margot M, et al. Among authors: scheffzek k. Mol Cell. 2022 Apr 7;82(7):1288-1296.e5. doi: 10.1016/j.molcel.2022.03.011. Epub 2022 Mar 29. Mol Cell. 2022. PMID: 35353986 Free article.

4

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.

Pena V, Hothorn M, Eberth A, Kaschau N, Parret A, Gremer L, Bonneau F, Ahmadian MR, Scheffzek K. Pena V, et al. Among authors: scheffzek k. EMBO Rep. 2008 Apr;9(4):350-5. doi: 10.1038/embor.2008.20. Epub 2008 Mar 7. EMBO Rep. 2008. PMID: 18323856 Free PMC article.

5

Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin.

Welti S, Kühn S, D'Angelo I, Brügger B, Kaufmann D, Scheffzek K. Welti S, et al. Among authors: scheffzek k. Hum Mutat. 2011 Feb;32(2):191-7. doi: 10.1002/humu.21405. Epub 2011 Jan 18. Hum Mutat. 2011. PMID: 21089070

6

Restoring functional neurofibromin by protein transduction.

Mellert K, Lechner S, Lüdeke M, Lamla M, Möller P, Kemkemer R, Scheffzek K, Kaufmann D. Mellert K, et al. Among authors: scheffzek k. Sci Rep. 2018 Apr 18;8(1):6171. doi: 10.1038/s41598-018-24310-5. Sci Rep. 2018. PMID: 29670214 Free PMC article.

7

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.

Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK. Yan W, et al. Among authors: scheffzek k. Cell Rep. 2020 Jul 21;32(3):107909. doi: 10.1016/j.celrep.2020.107909. Cell Rep. 2020. PMID: 32697994 Free PMC article.

8

Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.

Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A. Hothorn M, et al. Among authors: scheffzek k. Science. 2009 Apr 24;324(5926):513-6. doi: 10.1126/science.1168120. Science. 2009. PMID: 19390046

9

The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation.

Dunzendorfer-Matt T, Mercado EL, Maly K, McCormick F, Scheffzek K. Dunzendorfer-Matt T, et al. Among authors: scheffzek k. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7497-502. doi: 10.1073/pnas.1607298113. Epub 2016 Jun 16. Proc Natl Acad Sci U S A. 2016. PMID: 27313208 Free PMC article.

10

NMR resonance assignments of the EVH1 domain of neurofibromin's recruitment factor Spred1.

Führer S, Ahammer L, Ausserbichler A, Scheffzek K, Dunzendorfer-Matt T, Tollinger M. Führer S, et al. Among authors: scheffzek k. Biomol NMR Assign. 2017 Oct;11(2):305-308. doi: 10.1007/s12104-017-9768-1. Epub 2017 Aug 22. Biomol NMR Assign. 2017. PMID: 28831766 Free PMC article.

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