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Crystal structure of a common GPCR-binding interface for G protein and arrestin.
Szczepek M, Beyrière F, Hofmann KP, Elgeti M, Kazmin R, Rose A, Bartl FJ, von Stetten D, Heck M, Sommer ME, Hildebrand PW, Scheerer P. Szczepek M, et al. Among authors: scheerer p. Nat Commun. 2014 Sep 10;5:4801. doi: 10.1038/ncomms5801. Nat Commun. 2014. PMID: 25205354 Free PMC article.
The Activation Pathway of Human Rhodopsin in Comparison to Bovine Rhodopsin.
Kazmin R, Rose A, Szczepek M, Elgeti M, Ritter E, Piechnick R, Hofmann KP, Scheerer P, Hildebrand PW, Bartl FJ. Kazmin R, et al. Among authors: scheerer p. J Biol Chem. 2015 Aug 14;290(33):20117-27. doi: 10.1074/jbc.M115.652172. Epub 2015 Jun 23. J Biol Chem. 2015. PMID: 26105054 Free PMC article.
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.
Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P. Clément K, et al. Among authors: scheerer p. Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7. Nat Med. 2018. PMID: 29736023 Clinical Trial.
127 results