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Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors.
Coelho SVA, Rust NM, Vellasco L, Papa MP, Pereira ASG, Silva Palazzo MFD, Juliano MA, Costa SM, Alves AMB, Cordeiro MT, Marques ETA, Scharfstein J, Arruda LB. Coelho SVA, et al. Among authors: scharfstein j. Pharmaceuticals (Basel). 2021 Jan 12;14(1):56. doi: 10.3390/ph14010056. Pharmaceuticals (Basel). 2021. PMID: 33445640 Free PMC article.
Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.
Monteiro AC, Scovino A, Raposo S, Gaze VM, Cruz C, Svensjö E, Narciso MS, Colombo AP, Pesquero JB, Feres-Filho E, Nguyen KA, Sroka A, Potempa J, Scharfstein J. Monteiro AC, et al. Among authors: scharfstein j. J Immunol. 2009 Sep 15;183(6):3700-11. doi: 10.4049/jimmunol.0900895. Epub 2009 Aug 17. J Immunol. 2009. PMID: 19687097 Free PMC article.
Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy.
Andrade D, Serra R, Svensjö E, Lima AP, Ramos ES Jr, Fortes FS, Morandini AC, Morandi V, Soeiro Mde N, Tanowitz HB, Scharfstein J. Andrade D, et al. Among authors: scharfstein j. Br J Pharmacol. 2012 Mar;165(5):1333-47. doi: 10.1111/j.1476-5381.2011.01609.x. Br J Pharmacol. 2012. PMID: 21797847 Free PMC article.
Ecotin-like ISP of L. major promastigotes fine-tunes macrophage phagocytosis by limiting the pericellular release of bradykinin from surface-bound kininogens: a survival strategy based on the silencing of proinflammatory G-protein coupled kinin B2 and B1 receptors.
Svensjö E, Nogueira de Almeida L, Vellasco L, Juliano L, Scharfstein J. Svensjö E, et al. Among authors: scharfstein j. Mediators Inflamm. 2014;2014:143450. doi: 10.1155/2014/143450. Epub 2014 Sep 10. Mediators Inflamm. 2014. PMID: 25294952 Free PMC article.
Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi.
Monteiro AC, Schmitz V, Svensjo E, Gazzinelli RT, Almeida IC, Todorov A, de Arruda LB, Torrecilhas AC, Pesquero JB, Morrot A, Bouskela E, Bonomo A, Lima AP, Müller-Esterl W, Scharfstein J. Monteiro AC, et al. Among authors: scharfstein j. J Immunol. 2006 Nov 1;177(9):6325-35. doi: 10.4049/jimmunol.177.9.6325. J Immunol. 2006. PMID: 17056563
Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses.
Monteiro AC, Schmitz V, Morrot A, de Arruda LB, Nagajyothi F, Granato A, Pesquero JB, Müller-Esterl W, Tanowitz HB, Scharfstein J. Monteiro AC, et al. Among authors: scharfstein j. PLoS Pathog. 2007 Nov;3(11):e185. doi: 10.1371/journal.ppat.0030185. PLoS Pathog. 2007. PMID: 18052532 Free PMC article.
Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex.
Svensjö E, Batista PR, Brodskyn CI, Silva R, Lima AP, Schmitz V, Saraiva E, Pesquero JB, Mori MA, Müller-Esterl W, Scharfstein J. Svensjö E, et al. Among authors: scharfstein j. Microbes Infect. 2006 Jan;8(1):206-20. doi: 10.1016/j.micinf.2005.06.016. Epub 2005 Sep 8. Microbes Infect. 2006. PMID: 16203170 Free article.
114 results