Schaffhauser H - Search Results

1

A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios.

Tosstorff A, Rudolph MG, Cole JC, Reutlinger M, Kramer C, Schaffhauser H, Nilly A, Flohr A, Kuhn B. Tosstorff A, et al. Among authors: schaffhauser h. J Comput Aided Mol Des. 2022 Oct;36(10):753-765. doi: 10.1007/s10822-022-00478-x. Epub 2022 Sep 25. J Comput Aided Mol Des. 2022. PMID: 36153472

2

Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor.

Flohr A, Hutter R, Mueller B, Bohnert C, Pellisson M, Schaffhauser H. Flohr A, et al. Among authors: schaffhauser h. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5415-5419. doi: 10.1016/j.bmcl.2017.11.008. Epub 2017 Nov 6. Bioorg Med Chem Lett. 2017. PMID: 29146472

3

Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

Zhao Z, Wisnoski DD, O'Brien JA, Lemaire W, Williams DL Jr, Jacobson MA, Wittman M, Ha SN, Schaffhauser H, Sur C, Pettibone DJ, Duggan ME, Conn PJ, Hartman GD, Lindsley CW. Zhao Z, et al. Among authors: schaffhauser h. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1386-91. doi: 10.1016/j.bmcl.2006.11.081. Epub 2006 Dec 3. Bioorg Med Chem Lett. 2007. PMID: 17210250

4

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.

Pinkerton AB, Vernier JM, Schaffhauser H, Rowe BA, Campbell UC, Rodriguez DE, Lorrain DS, Baccei CS, Daggett LP, Bristow LJ. Pinkerton AB, et al. Among authors: schaffhauser h. J Med Chem. 2004 Aug 26;47(18):4595-9. doi: 10.1021/jm040088h. J Med Chem. 2004. PMID: 15317469

5

Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia.

Govek SP, Bonnefous C, Hutchinson JH, Kamenecka T, McQuiston J, Pracitto R, Zhao LX, Gardner MF, James JK, Daggett LP, Rowe BA, Schaffhauser H, Bristow LJ, Campbell UC, Rodriguez DE, Vernier JM. Govek SP, et al. Among authors: schaffhauser h. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4068-72. doi: 10.1016/j.bmcl.2005.06.017. Bioorg Med Chem Lett. 2005. PMID: 16005222

6

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones.

Pinkerton AB, Cube RV, Hutchinson JH, Rowe BA, Schaffhauser H, Zhao X, Daggett LP, Vernier JM. Pinkerton AB, et al. Among authors: schaffhauser h. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5329-32. doi: 10.1016/j.bmcl.2004.08.020. Bioorg Med Chem Lett. 2004. PMID: 15454221

7

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.

Pinkerton AB, Cube RV, Hutchinson JH, James JK, Gardner MF, Rowe BA, Schaffhauser H, Rodriguez DE, Campbell UC, Daggett LP, Vernier JM. Pinkerton AB, et al. Among authors: schaffhauser h. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1565-71. doi: 10.1016/j.bmcl.2005.01.077. Bioorg Med Chem Lett. 2005. PMID: 15745798

8

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.

Pinkerton AB, Cube RV, Hutchinson JH, James JK, Gardner MF, Schaffhauser H, Rowe BA, Daggett LP, Vernier JM. Pinkerton AB, et al. Among authors: schaffhauser h. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5867-72. doi: 10.1016/j.bmcl.2004.09.028. Bioorg Med Chem Lett. 2004. PMID: 15501058

9

Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.

Bonnefous C, Vernier JM, Hutchinson JH, Gardner MF, Cramer M, James JK, Rowe BA, Daggett LP, Schaffhauser H, Kamenecka TM. Bonnefous C, et al. Among authors: schaffhauser h. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4354-8. doi: 10.1016/j.bmcl.2005.06.062. Bioorg Med Chem Lett. 2005. PMID: 16046122

10

3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2).

Cube RV, Vernier JM, Hutchinson JH, Gardner MF, James JK, Rowe BA, Schaffhauser H, Daggett L, Pinkerton AB. Cube RV, et al. Among authors: schaffhauser h. Bioorg Med Chem Lett. 2005 May 2;15(9):2389-93. doi: 10.1016/j.bmcl.2005.02.078. Bioorg Med Chem Lett. 2005. PMID: 15837331

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