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Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I. Maculins T, et al. Among authors: schaeffer v. Cell Chem Biol. 2020 Nov 19;27(11):1441-1451.e7. doi: 10.1016/j.chembiol.2020.07.010. Epub 2020 Jul 28. Cell Chem Biol. 2020. PMID: 32726587 Free article.
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.
Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH. Freischmidt A, et al. Among authors: schaeffer v. Nat Neurosci. 2015 May;18(5):631-6. doi: 10.1038/nn.4000. Epub 2015 Mar 24. Nat Neurosci. 2015. PMID: 25803835
Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K. Stieglitz B, et al. Among authors: schaeffer v. Nature. 2013 Nov 21;503(7476):422-426. doi: 10.1038/nature12638. Epub 2013 Oct 20. Nature. 2013. PMID: 24141947 Free PMC article.
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, Clavaguera F, Sinnreich M, Kappos L, Goedert M, Tolnay M, Winkler DT. Ozcelik S, et al. Among authors: schaeffer v. PLoS One. 2013 May 7;8(5):e62459. doi: 10.1371/journal.pone.0062459. Print 2013. PLoS One. 2013. PMID: 23667480 Free PMC article.
68 results