Schaefer EM - Search Results

1

Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis.

Gilon C, Klazas M, Lahiani A, Schumacher-Klinger A, Merzbach S, Naoum JN, Ovadia H, Rubin L, Cornell-Kennon S, Schaefer EM, Katzhendler J, Marcinkiewicz C, Hoffman A, Lazarovici P. Gilon C, et al. Among authors: schaefer em. JACS Au. 2021 Nov 24;1(12):2361-2376. doi: 10.1021/jacsau.1c00496. eCollection 2021 Dec 27. JACS Au. 2021. PMID: 34977904 Free PMC article.

2

Neurotropic activity and safety of methylene-cycloalkylacetate (MCA) derivative 3-(3-allyl-2-methylenecyclohexyl) propanoic acid.

Lahiani A, Haham-Geula D, Lankri D, Cornell-Kennon S, Schaefer EM, Tsvelikhovsky D, Lazarovici P. Lahiani A, et al. Among authors: schaefer em. ACS Chem Neurosci. 2020 Sep 2;11(17):2577-2589. doi: 10.1021/acschemneuro.0c00255. Epub 2020 Aug 3. ACS Chem Neurosci. 2020. PMID: 32667774 Free PMC article.

3

Nerve growth factor pretreatment attenuates oxygen and glucose deprivation-induced c-Jun amino-terminal kinase 1 and stress-activated kinases p38alpha and p38beta activation and confers neuroprotection in the pheochromocytoma PC12 Model.

Tabakman R, Jiang H, Schaefer E, Levine RA, Lazarovici P. Tabakman R, et al. J Mol Neurosci. 2004;22(3):237-50. doi: 10.1385/jmn:22:3:237. J Mol Neurosci. 2004. PMID: 14997018

4

An algebraic model to determine substrate kinetic parameters by global nonlinear fit of progress curves.

Reytor González ML, Cornell-Kennon S, Schaefer E, Kuzmič P. Reytor González ML, et al. Anal Biochem. 2017 Feb 1;518:16-24. doi: 10.1016/j.ab.2016.11.001. Epub 2016 Nov 4. Anal Biochem. 2017. PMID: 27823930

5

Mitogen-activated protein kinases (MAPK) as predictors of clinical outcome in serous ovarian carcinoma in effusions.

Givant-Horwitz V, Davidson B, Lazarovici P, Schaefer E, Nesland JM, Tropé CG, Reich R. Givant-Horwitz V, et al. Gynecol Oncol. 2003 Oct;91(1):160-72. doi: 10.1016/s0090-8258(03)00434-7. Gynecol Oncol. 2003. PMID: 14529677

6

Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma.

Davidson B, Givant-Horwitz V, Lazarovici P, Risberg B, Nesland JM, Trope CG, Schaefer E, Reich R. Davidson B, et al. Clin Exp Metastasis. 2003;20(7):621-31. doi: 10.1023/a:1027347932543. Clin Exp Metastasis. 2003. PMID: 14669793

7

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.

Wittlinger F, Ogboo BC, Shevchenko E, Damghani T, Pham CD, Schaeffner IK, Oligny BT, Chitnis SP, Beyett TS, Rasch A, Buckley B, Urul DA, Shaurova T, May EW, Schaefer EM, Eck MJ, Hershberger PA, Poso A, Laufer SA, Heppner DE. Wittlinger F, et al. Among authors: schaefer em. Commun Chem. 2024 Feb 20;7(1):38. doi: 10.1038/s42004-024-01108-3. Commun Chem. 2024. PMID: 38378740 Free PMC article.

8

Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors.

Hoyt KW, Urul DA, Ogboo BC, Wittlinger F, Laufer SA, Schaefer EM, May EW, Heppner DE. Hoyt KW, et al. Among authors: schaefer em. J Med Chem. 2024 Jan 11;67(1):2-16. doi: 10.1021/acs.jmedchem.3c01502. Epub 2023 Dec 22. J Med Chem. 2024. PMID: 38134304 Review.

9

Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).

Heppner DE, Wittlinger F, Beyett TS, Shaurova T, Urul DA, Buckley B, Pham CD, Schaeffner IK, Yang B, Ogboo BC, May EW, Schaefer EM, Eck MJ, Laufer SA, Hershberger PA. Heppner DE, et al. Among authors: schaefer em. ACS Med Chem Lett. 2022 Nov 10;13(12):1856-1863. doi: 10.1021/acsmedchemlett.2c00213. eCollection 2022 Dec 8. ACS Med Chem Lett. 2022. PMID: 36518696 Free PMC article.

10

Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes.

Rubio M, Avitabile D, Fischer K, Emmanuel G, Gude N, Miyamoto S, Mishra S, Schaefer EM, Brown JH, Sussman MA. Rubio M, et al. Among authors: schaefer em. J Mol Cell Cardiol. 2009 Jul;47(1):96-103. doi: 10.1016/j.yjmcc.2009.02.022. Epub 2009 Mar 6. J Mol Cell Cardiol. 2009. PMID: 19269295 Free PMC article.

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