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Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity.
Wang S, Klein SO, Urban S, Staudt M, Barthes NPF, Willmann D, Bacher J, Sum M, Bauer H, Peng L, Rennar GA, Gratzke C, Schüle KM, Zhang L, Einsle O, Greschik H, MacLeod C, Thomson CG, Jung M, Metzger E, Schüle R. Wang S, et al. Among authors: schule km. Nat Commun. 2024 Jan 2;15(1):43. doi: 10.1038/s41467-023-44243-6. Nat Commun. 2024. PMID: 38167811 Free PMC article.
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.
Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, von Maessenhausen A, Urban S, Schott AK, Espejo A, Eberlin A, Wohlwend D, Schüle KM, Schleicher M, Perner S, Bedford MT, Jung M, Dengjel J, Flaig R, Imhof A, Einsle O, Schüle R. Metzger E, et al. Among authors: schule km. Nat Struct Mol Biol. 2016 Feb;23(2):132-9. doi: 10.1038/nsmb.3153. Epub 2016 Jan 11. Nat Struct Mol Biol. 2016. PMID: 26751641
Eomes restricts Brachyury functions at the onset of mouse gastrulation.
Schüle KM, Weckerle J, Probst S, Wehmeyer AE, Zissel L, Schröder CM, Tekman M, Kim GJ, Schlägl IM, Sagar, Arnold SJ. Schüle KM, et al. Dev Cell. 2023 Sep 25;58(18):1627-1642.e7. doi: 10.1016/j.devcel.2023.07.023. Epub 2023 Aug 25. Dev Cell. 2023. PMID: 37633271