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Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation.
Brain Behav Immun. 2024 Feb;116:385-401. doi: 10.1016/j.bbi.2023.12.028. Epub 2023 Dec 23.
Brain Behav Immun. 2024.
PMID: 38145855
Selective TLR4 Antagonism Prevents and Reverses Morphine-Induced Persistent Postoperative Cognitive Dysfunction, Dysregulation of Synaptic Elements, and Impaired BDNF Signaling in Aged Male Rats.
Muscat SM, Deems NP, Butler MJ, Scaria EA, Bettes MN, Cleary SP, Bockbrader RH, Maier SF, Barrientos RM.
Muscat SM, et al. Among authors: scaria ea.
J Neurosci. 2023 Jan 4;43(1):155-172. doi: 10.1523/JNEUROSCI.1151-22.2022. Epub 2022 Nov 16.
J Neurosci. 2023.
PMID: 36384680
Free PMC article.
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