Scarfe GB - Search Results

1

Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.

Degorce SL, Aagaard A, Anjum R, Cumming IA, Diène CR, Fallan C, Johnson T, Leuchowius KJ, Orton AL, Pearson S, Robb GR, Rosen A, Scarfe GB, Scott JS, Smith JM, Steward OR, Terstiege I, Tucker MJ, Turner P, Wilkinson SD, Wrigley GL, Xue Y. Degorce SL, et al. Among authors: scarfe gb. Bioorg Med Chem. 2020 Dec 1;28(23):115815. doi: 10.1016/j.bmc.2020.115815. Epub 2020 Oct 15. Bioorg Med Chem. 2020. PMID: 33091850

2

CYP-Mediated Sulfoximine Deimination of AZD6738.

Jones BC, Markandu R, Gu C, Scarfe G. Jones BC, et al. Drug Metab Dispos. 2017 Nov;45(11):1133-1138. doi: 10.1124/dmd.117.077776. Epub 2017 Aug 23. Drug Metab Dispos. 2017. PMID: 28835442

3

In vitro evaluation of the inhibition and induction potential of olaparib, a potent poly(ADP-ribose) polymerase inhibitor, on cytochrome P450.

McCormick A, Swaisland H, Reddy VP, Learoyd M, Scarfe G. McCormick A, et al. Xenobiotica. 2018 Jun;48(6):555-564. doi: 10.1080/00498254.2017.1346332. Epub 2017 Jul 25. Xenobiotica. 2018. PMID: 28657402

4

The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture.

Pichard-Garcia L, Weaver RJ, Eckett N, Scarfe G, Fabre JM, Lucas C, Maurel P. Pichard-Garcia L, et al. Drug Metab Dispos. 2004 Jan;32(1):80-8. doi: 10.1124/dmd.32.1.80. Drug Metab Dispos. 2004. PMID: 14709624

5

Physiologically Based Pharmacokinetic Modeling for Olaparib Dosing Recommendations: Bridging Formulations, Drug Interactions, and Patient Populations.

Pilla Reddy V, Bui K, Scarfe G, Zhou D, Learoyd M. Pilla Reddy V, et al. Clin Pharmacol Ther. 2019 Jan;105(1):229-241. doi: 10.1002/cpt.1103. Epub 2018 Aug 9. Clin Pharmacol Ther. 2019. PMID: 29717476 Free PMC article.

6

Investigation of the quantitative metabolic fate and urinary excretion of 3-methyl-4-trifluoromethylaniline and 3-methyl-4-trifluoromethylacetanilide in the rat.

Scarfe GB, Lindon JC, Nicholson JK, Wright B, Clayton E, Wilson ID. Scarfe GB, et al. Drug Metab Dispos. 1999 Oct;27(10):1171-8. Drug Metab Dispos. 1999. PMID: 10497144

7

Phase I study of orally administered ¹⁴Carbon-isotope labelled-vistusertib (AZD2014), a dual TORC1/2 kinase inhibitor, to assess the absorption, metabolism, excretion, and pharmacokinetics in patients with advanced solid malignancies.

MacDonald A, Scarfe G, Magirr D, Sarvotham T, Charlton J, Brugger W, Dean E. MacDonald A, et al. Cancer Chemother Pharmacol. 2019 Apr;83(4):787-795. doi: 10.1007/s00280-019-03781-x. Epub 2019 Feb 13. Cancer Chemother Pharmacol. 2019. PMID: 30758651 Clinical Trial.

8

Virtual chromatographic resolution enhancement in cryoflow LC-NMR experiments via statistical total correlation spectroscopy.

Cloarec O, Campbell A, Tseng LH, Braumann U, Spraul M, Scarfe G, Weaver R, Nicholson JK. Cloarec O, et al. Anal Chem. 2007 May 1;79(9):3304-11. doi: 10.1021/ac061928y. Epub 2007 Mar 30. Anal Chem. 2007. PMID: 17394288

9

High-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for the analysis of xenobiotic metabolites in rat urine: application to the metabolites of 4-bromoaniline.

Nicholson JK, Lindon JC, Scarfe G, Wilson ID, Abou-Shakra F, Castro-Perez J, Eaton A, Preece S. Nicholson JK, et al. Analyst. 2000 Feb;125(2):235-6. doi: 10.1039/a909494f. Analyst. 2000. PMID: 10820889

10

19F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4-trifluoromethylaniline in rat: a urinary excretion balance study without the use of radiolabelling.

Scarfe GB, Wright B, Clayton E, Taylor S, Wilson ID, Lindon JC, Nicholson JK. Scarfe GB, et al. Xenobiotica. 1998 Apr;28(4):373-88. doi: 10.1080/004982598239489. Xenobiotica. 1998. PMID: 9604301

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