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D-mannose suppresses macrophage IL-1β production.
Torretta S, Scagliola A, Ricci L, Mainini F, Di Marco S, Cuccovillo I, Kajaste-Rudnitski A, Sumpton D, Ryan KM, Cardaci S. Torretta S, et al. Among authors: scagliola a. Nat Commun. 2020 Dec 11;11(1):6343. doi: 10.1038/s41467-020-20164-6. Nat Commun. 2020. PMID: 33311467 Free PMC article.
Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.
Scagliola A, Miluzio A, Ventura G, Oliveto S, Cordiglieri C, Manfrini N, Cirino D, Ricciardi S, Valenti L, Baselli G, D'Ambrosio R, Maggioni M, Brina D, Bresciani A, Biffo S. Scagliola A, et al. Nat Commun. 2021 Aug 12;12(1):4878. doi: 10.1038/s41467-021-25195-1. Nat Commun. 2021. PMID: 34385447 Free PMC article.
High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Brina D, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Biffo S. Manfrini N, et al. Among authors: scagliola a. Dev Comp Immunol. 2017 Dec;77:69-76. doi: 10.1016/j.dci.2017.07.022. Epub 2017 Jul 22. Dev Comp Immunol. 2017. PMID: 28743432
Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Adler T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, Biffo S. Manfrini N, et al. Among authors: scagliola a. Data Brief. 2017 Aug 30;14:653-658. doi: 10.1016/j.dib.2017.08.023. eCollection 2017 Oct. Data Brief. 2017. PMID: 28924581 Free PMC article.
The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.
Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F. Clarke K, et al. Among authors: scagliola a. Cell Rep. 2017 Nov 7;21(6):1507-1520. doi: 10.1016/j.celrep.2017.10.040. Cell Rep. 2017. PMID: 29117557 Free PMC article.
Translating the Game: Ribosomes as Active Players.
Calamita P, Gatti G, Miluzio A, Scagliola A, Biffo S. Calamita P, et al. Among authors: scagliola a. Front Genet. 2018 Nov 15;9:533. doi: 10.3389/fgene.2018.00533. eCollection 2018. Front Genet. 2018. PMID: 30498507 Free PMC article. Review.
15 results