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ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
Hanson A, Elpek K, Duong E, Shallberg L, Fan M, Johnson C, Wallace M, Mabry GR, Sazinsky S, Pepper L, Shu CJ, Sathyanarayanan S, Zuerndorfer S, Simpson T, Gostissa M, Briskin M, Law D, Michaelson J, Harvey CJ. Hanson A, et al. Among authors: sazinsky s. PLoS One. 2020 Sep 24;15(9):e0239595. doi: 10.1371/journal.pone.0239595. eCollection 2020. PLoS One. 2020. PMID: 32970735 Free PMC article.
Rapid evolution of functional complexity in a domain family.
Ernst A, Sazinsky SL, Hui S, Currell B, Dharsee M, Seshagiri S, Bader GD, Sidhu SS. Ernst A, et al. Among authors: sazinsky sl. Sci Signal. 2009 Sep 8;2(87):ra50. doi: 10.1126/scisignal.2000416. Sci Signal. 2009. PMID: 19738200
A specificity map for the PDZ domain family.
Tonikian R, Zhang Y, Sazinsky SL, Currell B, Yeh JH, Reva B, Held HA, Appleton BA, Evangelista M, Wu Y, Xin X, Chan AC, Seshagiri S, Lasky LA, Sander C, Boone C, Bader GD, Sidhu SS. Tonikian R, et al. Among authors: sazinsky sl. PLoS Biol. 2008 Sep 30;6(9):e239. doi: 10.1371/journal.pbio.0060239. PLoS Biol. 2008. PMID: 18828675 Free PMC article.
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