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Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation.
Chen YF, Ghazala M, Friedrich RM, Cordova BA, Petroze FN, Srinivasan R, Allan KC, Yan DF, Sax JL, Carr K, Tomchuck SL, Fedorov Y, Huang AY, Desai AB, Adams DJ. Chen YF, et al. Among authors: sax jl. Nat Chem Biol. 2024 Mar 25. doi: 10.1038/s41589-024-01586-5. Online ahead of print. Nat Chem Biol. 2024. PMID: 38528120
Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages.
Weidner L, Lorenz J, Quach S, Braun FK, Rothhammer-Hampl T, Ammer LM, Vollmann-Zwerenz A, Bartos LM, Dekorsy FJ, Holzgreve A, Kirchleitner SV, Thon N, Greve T, Ruf V, Herms J, Bader S, Milenkovic VM, von Baumgarten L, Menevse AN, Hussein A, Sax J, Wetzel CH, Rupprecht R, Proescholdt M, Schmidt NO, Beckhove P, Hau P, Tonn JC, Bartenstein P, Brendel M, Albert NL, Riemenschneider MJ. Weidner L, et al. Among authors: sax j. Acta Neuropathol Commun. 2023 Sep 11;11(1):147. doi: 10.1186/s40478-023-01651-5. Acta Neuropathol Commun. 2023. PMID: 37697350 Free PMC article.
Safety and Immunogenicity of Radiation-Attenuated PfSPZ Vaccine in Equatoguinean Infants, Children, and Adults.
Jongo SA, Urbano Nsue Ndong Nchama V, Church LWP, Olotu A, Manock SR, Schindler T, Mtoro A, Kc N, Devinsky O, Zan E, Hamad A, Nyakarungu E, Mpina M, Deal A, Bijeri JR, Ondo Mangue ME, Ntutumu Pasialo BE, Nguema GN, Rivas MR, Chemba M, Ramadhani KK, James ER, Stabler TC, Abebe Y, Riyahi P, Saverino ES, Sax J, Hosch S, Tumbo A, Gondwe L, Segura JL, Falla CC, Phiri WP, Hergott DEB, García GA, Maas C, Murshedkar T, Billingsley PF, Tanner M, Ayekaba MO, Sim BKL, Daubenberger C, Richie TL, Abdulla S, Hoffman SL. Jongo SA, et al. Among authors: sax j. Am J Trop Med Hyg. 2023 May 9;109(1):138-146. doi: 10.4269/ajtmh.22-0773. Print 2023 Jul 5. Am J Trop Med Hyg. 2023. PMID: 37160281 Free PMC article. Clinical Trial.
TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma.
Menevse AN, Ammer LM, Vollmann-Zwerenz A, Kupczyk M, Lorenz J, Weidner L, Hussein A, Sax J, Mühlbauer J, Heuschneider N, Rohrmus C, Mai LS, Jachnik B, Stamova S, Volpin V, Durst FC, Sorrentino A, Xydia M, Milenkovic VM, Bader S, Braun FK, Wetzel C, Albert NL, Tonn JC, Bartenstein P, Proescholdt M, Schmidt NO, Linker RA, Riemenschneider MJ, Beckhove P, Hau P. Menevse AN, et al. Among authors: sax j. Acta Neuropathol Commun. 2023 May 8;11(1):75. doi: 10.1186/s40478-023-01550-9. Acta Neuropathol Commun. 2023. PMID: 37158962 Free PMC article.
Engineering site-selective incorporation of fluorine into polyketides.
Sirirungruang S, Ad O, Privalsky TM, Ramesh S, Sax JL, Dong H, Baidoo EEK, Amer B, Khosla C, Chang MCY. Sirirungruang S, et al. Among authors: sax jl. Nat Chem Biol. 2022 Aug;18(8):886-893. doi: 10.1038/s41589-022-01070-y. Epub 2022 Jul 11. Nat Chem Biol. 2022. PMID: 35817967 Free PMC article.
58 results