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α-Synuclein aggregation nucleates through liquid-liquid phase separation.
Nat Chem. 2020 Aug;12(8):705-716. doi: 10.1038/s41557-020-0465-9. Epub 2020 Jun 8.
Nat Chem. 2020.
PMID: 32514159
Effect of Disease-Associated P123H and V70M Mutations on β-Synuclein Fibrillation.
Sharma K, Mehra S, Sawner AS, Markam PS, Panigrahi R, Navalkar A, Chatterjee D, Kumar R, Kadu P, Patel K, Ray S, Kumar A, Maji SK.
Sharma K, et al. Among authors: sawner as.
ACS Chem Neurosci. 2020 Sep 16;11(18):2836-2848. doi: 10.1021/acschemneuro.0c00405. Epub 2020 Sep 6.
ACS Chem Neurosci. 2020.
PMID: 32833434
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α-Synuclein Aggregation Intermediates form Fibril Polymorphs with Distinct Prion-like Properties.
Mehra S, Ahlawat S, Kumar H, Datta D, Navalkar A, Singh N, Patel K, Gadhe L, Kadu P, Kumar R, Jha NN, Sakunthala A, Sawner AS, Padinhateeri R, Udgaonkar JB, Agarwal V, Maji SK.
Mehra S, et al. Among authors: sawner as.
J Mol Biol. 2022 Oct 15;434(19):167761. doi: 10.1016/j.jmb.2022.167761. Epub 2022 Jul 27.
J Mol Biol. 2022.
PMID: 35907572
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Modulating α-Synuclein Liquid-Liquid Phase Separation.
Sawner AS, Ray S, Yadav P, Mukherjee S, Panigrahi R, Poudyal M, Patel K, Ghosh D, Kummerant E, Kumar A, Riek R, Maji SK.
Sawner AS, et al.
Biochemistry. 2021 Dec 7;60(48):3676-3696. doi: 10.1021/acs.biochem.1c00434. Epub 2021 Aug 25.
Biochemistry. 2021.
PMID: 34431665
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Structural and Functional Insights into α-Synuclein Fibril Polymorphism.
Mehra S, Gadhe L, Bera R, Sawner AS, Maji SK.
Mehra S, et al. Among authors: sawner as.
Biomolecules. 2021 Sep 28;11(10):1419. doi: 10.3390/biom11101419.
Biomolecules. 2021.
PMID: 34680054
Free PMC article.
Review.
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Intermediates of α-synuclein aggregation: Implications in Parkinson's disease pathogenesis.
Gadhe L, Sakunthala A, Mukherjee S, Gahlot N, Bera R, Sawner AS, Kadu P, Maji SK.
Gadhe L, et al. Among authors: sawner as.
Biophys Chem. 2022 Feb;281:106736. doi: 10.1016/j.bpc.2021.106736. Epub 2021 Dec 6.
Biophys Chem. 2022.
PMID: 34923391
Review.
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Liquid-liquid Phase Separation of α-Synuclein: A New Mechanistic Insight for α-Synuclein Aggregation Associated with Parkinson's Disease Pathogenesis.
Mukherjee S, Sakunthala A, Gadhe L, Poudyal M, Sawner AS, Kadu P, Maji SK.
Mukherjee S, et al. Among authors: sawner as.
J Mol Biol. 2023 Jan 15;435(1):167713. doi: 10.1016/j.jmb.2022.167713. Epub 2022 Jul 3.
J Mol Biol. 2023.
PMID: 35787838
Review.
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Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu.
Poudyal M, Patel K, Gadhe L, Sawner AS, Kadu P, Datta D, Mukherjee S, Ray S, Navalkar A, Maiti S, Chatterjee D, Devi J, Bera R, Gahlot N, Joseph J, Padinhateeri R, Maji SK.
Poudyal M, et al. Among authors: sawner as.
Nat Commun. 2023 Oct 4;14(1):6199. doi: 10.1038/s41467-023-41864-9.
Nat Commun. 2023.
PMID: 37794023
Free PMC article.
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