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Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.
Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K. Nakamura S, et al. Among authors: sawaguchi a. Cell Stem Cell. 2014 Apr 3;14(4):535-48. doi: 10.1016/j.stem.2014.01.011. Epub 2014 Feb 13. Cell Stem Cell. 2014. PMID: 24529595 Free article.
Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets.
Hirata S, Murata T, Suzuki D, Nakamura S, Jono-Ohnishi R, Hirose H, Sawaguchi A, Nishimura S, Sugimoto N, Eto K. Hirata S, et al. Among authors: sawaguchi a. Stem Cells Transl Med. 2017 Mar;6(3):720-730. doi: 10.5966/sctm.2016-0104. Epub 2016 Oct 5. Stem Cells Transl Med. 2017. PMID: 28297575 Free PMC article.
iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity.
Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, Akasaka M, Nakamura S, Higashi N, Xu H, Matsumoto T, Fujio K, Manz MG, Hotta A, Takizawa H, Eto K, Sugimoto N. Suzuki D, et al. Among authors: sawaguchi a. Stem Cell Reports. 2020 Jan 14;14(1):49-59. doi: 10.1016/j.stemcr.2019.11.011. Epub 2019 Dec 26. Stem Cell Reports. 2020. PMID: 31883921 Free PMC article.
Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs.
Sone M, Nakamura S, Umeda S, Ginya H, Oshima M, Kanashiro MA, Paul SK, Hashimoto K, Nakamura E, Harada Y, Tsujimura K, Saraya A, Yamaguchi T, Sugimoto N, Sawaguchi A, Iwama A, Eto K, Takayama N. Sone M, et al. Among authors: sawaguchi a. Stem Cell Reports. 2021 Dec 14;16(12):2861-2870. doi: 10.1016/j.stemcr.2021.11.001. Epub 2021 Dec 2. Stem Cell Reports. 2021. PMID: 34861163 Free PMC article.
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K. Takayama N, et al. Among authors: sawaguchi a. J Exp Med. 2010 Dec 20;207(13):2817-30. doi: 10.1084/jem.20100844. Epub 2010 Nov 22. J Exp Med. 2010. PMID: 21098095 Free PMC article.
Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cells.
Hirose S, Takayama N, Nakamura S, Nagasawa K, Ochi K, Hirata S, Yamazaki S, Yamaguchi T, Otsu M, Sano S, Takahashi N, Sawaguchi A, Ito M, Kato T, Nakauchi H, Eto K. Hirose S, et al. Among authors: sawaguchi a. Stem Cell Reports. 2013 Dec 5;1(6):499-508. doi: 10.1016/j.stemcr.2013.10.010. eCollection 2013. Stem Cell Reports. 2013. PMID: 24371805 Free PMC article.
Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, Eto K. Ito Y, et al. Among authors: sawaguchi a. Cell. 2018 Jul 26;174(3):636-648.e18. doi: 10.1016/j.cell.2018.06.011. Epub 2018 Jul 12. Cell. 2018. PMID: 30017246 Free article.
121 results