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Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity.
Funcke JB, Moepps B, Roos J, von Schnurbein J, Verstraete K, Fröhlich-Reiterer E, Kohlsdorf K, Nunziata A, Brandt S, Tsirigotaki A, Dansercoer A, Suppan E, Haris B, Debatin KM, Savvides SN, Farooqi IS, Hussain K, Gierschik P, Fischer-Posovszky P, Wabitsch M. Funcke JB, et al. Among authors: savvides sn. N Engl J Med. 2023 Jun 15;388(24):2253-2261. doi: 10.1056/NEJMoa2204041. N Engl J Med. 2023. PMID: 37314706
Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions.
Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L. Szaruga M, et al. Among authors: savvides sn. Cell. 2021 Apr 15;184(8):2257-2258. doi: 10.1016/j.cell.2021.03.058. Cell. 2021. PMID: 33861967 Free article. No abstract available.
Expression, purification, crystallization and structure determination of two glutathione S-transferase-like proteins from Shewanella oneidensis.
Remmerie B, Vandenbroucke K, De Smet L, Carpentier W, De Vos D, Stout J, Van Beeumen J, Savvides SN. Remmerie B, et al. Among authors: savvides sn. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):548-53. doi: 10.1107/S1744309108014589. Epub 2008 May 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18540073 Free PMC article.
Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding.
Yperman K, Papageorgiou AC, Merceron R, De Munck S, Bloch Y, Eeckhout D, Jiang Q, Tack P, Grigoryan R, Evangelidis T, Van Leene J, Vincze L, Vandenabeele P, Vanhaecke F, Potocký M, De Jaeger G, Savvides SN, Tripsianes K, Pleskot R, Van Damme D. Yperman K, et al. Among authors: savvides sn. Nat Commun. 2021 May 24;12(1):3050. doi: 10.1038/s41467-021-23314-6. Nat Commun. 2021. PMID: 34031427 Free PMC article.
133 results