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Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy.
Nat Biotechnol. 2023 Jul;41(7):932-943. doi: 10.1038/s41587-022-01567-w. Epub 2023 Jan 2.
Nat Biotechnol. 2023.
PMID: 36593402
Free PMC article.
A strategy for the selection of monovalent antibodies that span protein dimer interfaces.
Spangler JB, Moraga I, Jude KM, Savvides CS, Garcia KC.
Spangler JB, et al. Among authors: savvides cs.
J Biol Chem. 2019 Sep 20;294(38):13876-13886. doi: 10.1074/jbc.RA119.009213. Epub 2019 Aug 6.
J Biol Chem. 2019.
PMID: 31387945
Free PMC article.
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Immune receptor inhibition through enforced phosphatase recruitment.
Fernandes RA, Su L, Nishiga Y, Ren J, Bhuiyan AM, Cheng N, Kuo CJ, Picton LK, Ohtsuki S, Majzner RG, Rietberg SP, Mackall CL, Yin Q, Ali LR, Yang X, Savvides CS, Sage J, Dougan M, Garcia KC.
Fernandes RA, et al. Among authors: savvides cs.
Nature. 2020 Oct;586(7831):779-784. doi: 10.1038/s41586-020-2851-2. Epub 2020 Oct 21.
Nature. 2020.
PMID: 33087934
Free PMC article.
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Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Yang X, Garner LI, Zvyagin IV, Paley MA, Komech EA, Jude KM, Zhao X, Fernandes RA, Hassman LM, Paley GL, Savvides CS, Brackenridge S, Quastel MN, Chudakov DM, Bowness P, Yokoyama WM, McMichael AJ, Gillespie GM, Garcia KC.
Yang X, et al. Among authors: savvides cs.
Nature. 2022 Dec;612(7941):771-777. doi: 10.1038/s41586-022-05501-7. Epub 2022 Dec 7.
Nature. 2022.
PMID: 36477533
Free PMC article.
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Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo.
Fernandes RA, Li C, Wang G, Yang X, Savvides CS, Glassman CR, Dong S, Luxenberg E, Sibener LV, Birnbaum ME, Benoist C, Mathis D, Garcia KC.
Fernandes RA, et al. Among authors: savvides cs.
Elife. 2020 Aug 10;9:e58463. doi: 10.7554/eLife.58463.
Elife. 2020.
PMID: 32773038
Free PMC article.
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Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.
Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC.
Spangler JB, et al. Among authors: savvides cs.
J Immunol. 2018 Oct 1;201(7):2094-2106. doi: 10.4049/jimmunol.1800578. Epub 2018 Aug 13.
J Immunol. 2018.
PMID: 30104245
Free PMC article.
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