Savinainen J - Search Results

1

Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain.

Della Pietra A, Savinainen J, Giniatullin R. Della Pietra A, et al. Among authors: savinainen j. Int J Mol Sci. 2022 Apr 15;23(8):4407. doi: 10.3390/ijms23084407. Int J Mol Sci. 2022. PMID: 35457225 Free PMC article. Review.

2

Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency.

Laitinen T, Navia-Paldanius D, Rytilahti R, Marjamaa JJ, Kařízková J, Parkkari T, Pantsar T, Poso A, Laitinen JT, Savinainen JR. Laitinen T, et al. Among authors: savinainen jr. Mol Pharmacol. 2014 Mar;85(3):510-9. doi: 10.1124/mol.113.090795. Epub 2013 Dec 24. Mol Pharmacol. 2014. PMID: 24368842

3

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL).

Savinainen JR, Kansanen E, Pantsar T, Navia-Paldanius D, Parkkari T, Lehtonen M, Laitinen T, Nevalainen T, Poso A, Levonen AL, Laitinen JT. Savinainen JR, et al. Mol Pharmacol. 2014 Nov;86(5):522-35. doi: 10.1124/mol.114.094284. Epub 2014 Aug 19. Mol Pharmacol. 2014. PMID: 25140003

4

Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

Korhonen J, Kuusisto A, van Bruchem J, Patel JZ, Laitinen T, Navia-Paldanius D, Laitinen JT, Savinainen JR, Parkkari T, Nevalainen TJ. Korhonen J, et al. Among authors: savinainen jr. Bioorg Med Chem. 2014 Dec 1;22(23):6694-6705. doi: 10.1016/j.bmc.2014.09.012. Epub 2014 Sep 16. Bioorg Med Chem. 2014. PMID: 25282655

5

Loratadine analogues as MAGL inhibitors.

Patel JZ, Ahenkorah S, Vaara M, Staszewski M, Adams Y, Laitinen T, Navia-Paldanius D, Parkkari T, Savinainen JR, Walczyński K, Laitinen JT, Nevalainen TJ. Patel JZ, et al. Among authors: savinainen jr. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1436-42. doi: 10.1016/j.bmcl.2015.02.037. Epub 2015 Feb 24. Bioorg Med Chem Lett. 2015. PMID: 25752982

6

Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase.

Navia-Paldanius D, Aaltonen N, Lehtonen M, Savinainen JR, Taschler U, Radner FP, Zimmermann R, Laitinen JT. Navia-Paldanius D, et al. Eur J Pharm Sci. 2015 Sep 18;77:180-8. doi: 10.1016/j.ejps.2015.06.005. Epub 2015 Jun 9. Eur J Pharm Sci. 2015. PMID: 26070239

7

A Sensitive and Versatile Fluorescent Activity Assay for ABHD6.

Savinainen JR, Navia-Paldanius D, Laitinen JT. Savinainen JR, et al. Methods Mol Biol. 2016;1412:169-78. doi: 10.1007/978-1-4939-3539-0_18. Methods Mol Biol. 2016. PMID: 27245903

8

A Sensitive and Versatile Fluorescent Activity Assay for ABHD12.

Savinainen JR, Navia-Paldanius D, Laitinen JT. Savinainen JR, et al. Methods Mol Biol. 2016;1412:179-89. doi: 10.1007/978-1-4939-3539-0_19. Methods Mol Biol. 2016. PMID: 27245904

9

In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048).

Aaltonen N, Kedzierska E, Orzelska-Górka J, Lehtonen M, Navia-Paldanius D, Jakupovic H, Savinainen JR, Nevalainen T, Laitinen JT, Parkkari T, Gynther M. Aaltonen N, et al. Among authors: savinainen jr. J Pharmacol Exp Ther. 2016 Oct;359(1):62-72. doi: 10.1124/jpet.116.233114. Epub 2016 Jul 22. J Pharmacol Exp Ther. 2016. PMID: 27451409

10

Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications.

Grimsey NL, Savinainen JR, Attili B, Ahamed M. Grimsey NL, et al. Among authors: savinainen jr. Drug Discov Today. 2020 Feb;25(2):330-343. doi: 10.1016/j.drudis.2019.10.004. Epub 2019 Oct 14. Drug Discov Today. 2020. PMID: 31622747 Review.

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