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Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.
Powell N, Pantazi E, Pavlidis P, Tsakmaki A, Li K, Yang F, Parker A, Pin C, Cozzetto D, Minns D, Stolarczyk E, Saveljeva S, Mohamed R, Lavender P, Afzali B, Digby-Bell J, Tjir-Li T, Kaser A, Friedman J, MacDonald TT, Bewick GA, Lord GM. Powell N, et al. Among authors: saveljeva s. Gut. 2020 Mar;69(3):578-590. doi: 10.1136/gutjnl-2019-318483. Epub 2019 Dec 2. Gut. 2020. PMID: 31792136 Free PMC article. Review.
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.
Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS. Grootjans J, et al. Among authors: saveljeva s. Science. 2019 Mar 1;363(6430):993-998. doi: 10.1126/science.aat7186. Science. 2019. PMID: 30819965 Free PMC article.
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P. Aden K, et al. Among authors: saveljeva s. J Exp Med. 2018 Nov 5;215(11):2868-2886. doi: 10.1084/jem.20171029. Epub 2018 Sep 25. J Exp Med. 2018. PMID: 30254094 Free PMC article.
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.
Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A. Tschurtschenthaler M, et al. Among authors: saveljeva s. J Exp Med. 2017 Feb;214(2):401-422. doi: 10.1084/jem.20160791. Epub 2017 Jan 12. J Exp Med. 2017. PMID: 28082357 Free PMC article.
Impaired Autophagy in CD11b+ Dendritic Cells Expands CD4+ Regulatory T Cells and Limits Atherosclerosis in Mice.
Clement M, Raffort J, Lareyre F, Tsiantoulas D, Newland S, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MKL, Ozsvar-Kozma M, Lam BYH, Yeo GSH, Binder CJ, Kaser A, Mallat Z. Clement M, et al. Among authors: saveljeva s. Circ Res. 2019 Nov 8;125(11):1019-1034. doi: 10.1161/CIRCRESAHA.119.315248. Epub 2019 Oct 15. Circ Res. 2019. PMID: 31610723 Free PMC article.
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation.
Saveljeva S, Sewell GW, Ramshorn K, Cader MZ, West JA, Clare S, Haag LM, de Almeida Rodrigues RP, Unger LW, Iglesias-Romero AB, Holland LM, Bourges C, Md-Ibrahim MN, Jones JO, Blumberg RS, Lee JC, Kaneider NC, Lawley TD, Bradley A, Dougan G, Kaser A. Saveljeva S, et al. Cell Metab. 2022 Jan 4;34(1):106-124.e10. doi: 10.1016/j.cmet.2021.12.009. Cell Metab. 2022. PMID: 34986329 Free PMC article.
FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.
Cader MZ, de Almeida Rodrigues RP, West JA, Sewell GW, Md-Ibrahim MN, Reikine S, Sirago G, Unger LW, Iglesias-Romero AB, Ramshorn K, Haag LM, Saveljeva S, Ebel JF, Rosenstiel P, Kaneider NC, Lee JC, Lawley TD, Bradley A, Dougan G, Modis Y, Griffin JL, Kaser A. Cader MZ, et al. Among authors: saveljeva s. Cell. 2020 Jan 23;180(2):278-295.e23. doi: 10.1016/j.cell.2019.12.017. Cell. 2020. PMID: 31978345 Free PMC article.
19 results