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Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling.
Klein M, Schermuly RT, Ellinghaus P, Milting H, Riedl B, Nikolova S, Pullamsetti SS, Weissmann N, Dony E, Savai R, Ghofrani HA, Grimminger F, Busch AE, Schäfer S. Klein M, et al. Among authors: savai r. Circulation. 2008 Nov 11;118(20):2081-90. doi: 10.1161/CIRCULATIONAHA.108.779751. Epub 2008 Oct 27. Circulation. 2008. PMID: 18955668
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
Pullamsetti SS, Savai R, Schaefer MB, Wilhelm J, Ghofrani HA, Weissmann N, Schudt C, Fleming I, Mayer K, Leiper J, Seeger W, Grimminger F, Schermuly RT. Pullamsetti SS, et al. Among authors: savai r. Circulation. 2011 Mar 22;123(11):1194-204. doi: 10.1161/CIRCULATIONAHA.110.941484. Epub 2011 Mar 7. Circulation. 2011. PMID: 21382892
The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
Pullamsetti SS, Savai R, Dumitrascu R, Dahal BK, Wilhelm J, Konigshoff M, Zakrzewicz D, Ghofrani HA, Weissmann N, Eickelberg O, Guenther A, Leiper J, Seeger W, Grimminger F, Schermuly RT. Pullamsetti SS, et al. Among authors: savai r. Sci Transl Med. 2011 Jun 15;3(87):87ra53. doi: 10.1126/scitranslmed.3001725. Sci Transl Med. 2011. PMID: 21677199
128 results